The squamous epithelium covering the skin and oral mucosa relies on epithelial stem cells
for tissue renewal. Dynamic changes in DNA methylation, histone methylation and …

Background: Epithelial tissues have the ability to self-renew throughout animal's life due to
the presence of the epithelial stem cells. Except for complicated genes regulation, the fate of …

Human skin is maintained by the differentiation and maturation of interfollicular stem and
progenitors cells. We used DeepCAGE, genome-wide profiling of histone modifications and …

In the era of tissue engineering and development of novel approaches for stem cell-driven
organ regeneration, it is important to understand how multipotent stem cells establish distinct …

Epithelial stem cells, such as those present in mammalian skin, intestine, or mammary
gland, are tissue stem cells capable of both long‐term self‐renewal and multi‐lineage …

Stem cell decline is an important cellular driver of aging-associated pathophysiology in
multiple tissues. Epigenetic regulation is central to establishing and maintaining stem cell …

In a cell, the chromatin state is controlled by the highly regulated interplay of epigenetic
mechanisms ranging from DNA methylation and incorporation of different histone variants to …

Epigenetic mechanisms controlling adult mammalian stem cell (SC) dynamics might be
critical for tissue regeneration but are poorly understood. Mouse skin and hair follicle SCs …

Emerging evidence is shedding light on a large and complex network of epigenetic
modifications at play in human stem cells. This “epigenetic landscape” governs the fine …

Embryonic stem (ES) cells are pluripotent cells that differentiate into all cell types of the
organism. In adult, multipotent tissue-specific stem cells undergo multi-lineage differentiation …