The contribution of T cells in severe malaria pathogenesis has been described. Here, we
provide evidence for the potential role of angiotensin II (Ang II) in modulating splenic T cell …

CD8+ T-cell response is critical in the pathogenesis of cerebral malaria during blood-stage.
Our group and other have been shown that angiotensin II (Ang II) and its receptor AT1 …

IFN-γ and T cells are both required for the development of experimental cerebral malaria
during Plasmodium berghei ANKA infection. Surprisingly, however, the role of IFN-γ in …

Successful recovery from malaria involves striking a balance between counteracting
cytokines. The cytokine imbalance contributes to pathological features, but their exact levels …

The infection of mice with Plasmodium berghei ANKA constitutes the best available mouse
model for human Plasmodium falciparum-mediated cerebral malaria, a devastating …

The resolution of malaria infection is dependent on a balance between proinflammatory and
regulatory immune responses. While early effector T cell responses are required for limiting …

T-cell immune responses are critical for protection of the host and for disease pathogenesis
during infection with Plasmodium species. We examined the regulation of CD4+ T-cell …

Infection with Plasmodium berghei ANKA (PbA) causes fatal cerebral malaria (CM). While a
pathogenic role for tumor necrosis factor (TNF) has been established, we asked whether a …

Previous studies have shown that IFN‐γ is essential for the pathogenesis of cerebral malaria
(CM) induced by Plasmodium berghei ANKA (PbA) in mice. However, the exact role of IFN‐γ …

Cerebral malaria (CM) is one complication of Plasmodium parasite infection that can lead to
strong inflammatory immune responses in the central nervous system (CNS), accompanied …