Background: Growth promoting signals from the epicardium are essential for driving
myocardial proliferation during embryogenesis. In adults, these signals become reactivated …

Significance: Heart disease is the primary cause of death in the industrialized world. Cardiac
failure is dictated by an uncompensated reduction in the number of viable and fully …

Background Myocardial infarction remains the leading cause of mortality in developed
countries despite recent advances in its prevention and treatment. Regenerative therapies …

Regenerative medicine for heart failure seeks to replace lost cardiomyocytes. Chemical
approaches for producing ample supplies of cells, such as pluripotent stem cells and …

Background—The adult epicardium is a potential source of cardiac progenitors after
myocardial infarction (MI). We tested the hypothesis that cardiomyocyte-specific …

Abstract Significance: Utilizing oxygen (O2) through mitochondrial oxidative phosphorylation
enables organisms to generate adenosine triphosphate (ATP) with a higher efficiency than …

Due to the limited self-renewal capacity of cardiomyocytes, the mammalian heart exhibits
impaired regeneration and insufficient ability to restore heart function after injury …

Endothelial cell (EC) dedifferentiation in relation to neovascularization is a poorly
understood process. In this report, we addressed the role of Wnt signaling in the …

Despite the explosion of knowledge in basic biological processes controlling tissue
regeneration and the growing interest in repairing/replacing diseased tissues and organs …

Various stem cell types have been tested for regenerating damaged myocardium after
myocardial infarction. However, the results of clinical trials have not been consistent, with …