Defining midbrain dopaminergic neuron diversity by single-cell gene expression profiling

JF Poulin, J Zou, J Drouin-Ouellet, KYA Kim, F Cicchetti… - Cell reports, 2014 - cell.com
Effective approaches to neuropsychiatric disorders require detailed understanding of the
cellular composition and circuitry of the complex mammalian brain. Here, we present a …

Single-cell RNA sequencing reveals midbrain dopamine neuron diversity emerging during mouse brain development

K Tiklová, ÅK Björklund, L Lahti, A Fiorenzano… - Nature …, 2019 - nature.com
Midbrain dopamine (mDA) neurons constitute a heterogenous group of cells that have been
intensely studied, not least because their degeneration causes major symptoms in …

Mapping projections of molecularly defined dopamine neuron subtypes using intersectional genetic approaches

JF Poulin, G Caronia, C Hofer, Q Cui, B Helm… - Nature …, 2018 - nature.com
Midbrain dopamine (DA) neurons have diverse functions that can in part be explained by
their heterogeneity. Although molecularly distinct subtypes of DA neurons have been …

Classification of midbrain dopamine neurons using single-cell gene expression profiling approaches

JF Poulin, Z Gaertner, OA Moreno-Ramos… - Trends in …, 2020 - cell.com
Dysfunctional dopamine (DA) signaling has been associated with a broad spectrum of
neuropsychiatric disorders, prompting investigations into how midbrain DA neuron …

[HTML][HTML] Molecular heterogeneity of midbrain dopaminergic neurons–Moving toward single cell resolution

A Anderegg, JF Poulin, R Awatramani - FEBS letters, 2015 - Elsevier
Since their discovery, midbrain dopamine (DA) neurons have been researched extensively,
in part because of their diverse functions and involvement in various neuropsychiatric …

Individual dopamine midbrain neurons: functional diversity and flexibility in health and disease

B Liss, J Roeper - Brain research reviews, 2008 - Elsevier
Dopaminergic midbrain neurons are involved in many important brain functions including
motor control, as well as emotive and cognitive tasks. They also play critical roles in major …

Single-cell genomic profiling of human dopamine neurons identifies a population that selectively degenerates in Parkinson's disease

T Kamath, A Abdulraouf, SJ Burris, J Langlieb… - Nature …, 2022 - nature.com
The loss of dopamine (DA) neurons within the substantia nigra pars compacta (SNpc) is a
defining pathological hallmark of Parkinson's disease (PD). Nevertheless, the molecular …

Single-cell sequencing of iPSC-dopamine neurons reconstructs disease progression and identifies HDAC4 as a regulator of Parkinson cell phenotypes

C Lang, KR Campbell, BJ Ryan, P Carling, M Attar… - Cell stem cell, 2019 - cell.com
Induced pluripotent stem cell (iPSC)-derived dopamine neurons provide an opportunity to
model Parkinson's disease (PD), but neuronal cultures are confounded by asynchronous …

Cell type-specific gene expression of midbrain dopaminergic neurons reveals molecules involved in their vulnerability and protection

CY Chung, H Seo, KC Sonntag, A Brooks… - Human molecular …, 2005 - academic.oup.com
Molecular differences between dopamine (DA) neurons may explain why the mesostriatal
DA neurons in the A9 region preferentially degenerate in Parkinson's disease (PD) and toxic …

Molecular basis for catecholaminergic neuron diversity

J Grimm, A Mueller, F Hefti… - Proceedings of the …, 2004 - National Acad Sciences
Catecholaminergic neurons control diverse cognitive, motor, and endocrine functions and
are associated with multiple psychiatric and neurodegenerative disorders. We present …