Aims In the adult heart, Notch signalling regulates the response to injury. Notch inhibition
leads to increased cardiomyocyte apoptosis, and exacerbates the development of cardiac …

Through local cell–cell interactions, the Notch signaling pathway controls tissue formation
and homeostasis during embryonic and adult life. In the heart, Notch1 is expressed in a …

Rationale: The Notch signaling pathway is important for cell–cell communication that
controls tissue formation and homeostasis during embryonic and adult life, but the precise …

In the damaged heart, cardiac adaptation relies primarily on cardiomyocyte hypertrophy. The
recent discovery of cardiac stem cells in the postnatal heart, however, suggests that these …

The identification of the molecular mechanisms controlling cardiomyocyte proliferation
during the embryonic, fetal, and early neonatal life appears of paramount interest in regard …

Notch signaling is a major intercellular coordination mechanism highly conserved
throughout evolution. In vertebrates, Notch signaling is physiologically involved in embryo …

Notch signaling is an evolutionarily ancient, highly conserved pathway important for
deciding cell fate, cellular development, differentiation, proliferation, apoptosis, adhesion …

Notch signaling is critical for proper heart development and recently has been reported to
participate in adult cardiac repair. Notch resides at the cell surface as a single pass …

In the developing heart, Notch signaling plays an essential role in several key
developmental processes, such as epithelial-to-mesenchymal transition and myocyte …

Pathological ventricle remodelling, which follows a cardiac insult, causes heart failure.
Despite the existence of multiple pharmaceutical approaches, heart failure is one of the …