Single cell genomics: advances and future perspectives

IC Macaulay, T Voet - PLoS genetics, 2014 - journals.plos.org
Advances in whole-genome and whole-transcriptome amplification have permitted the
sequencing of the minute amounts of DNA and RNA present in a single cell, offering a …

Single cell transcriptomics comes of age

S Aldridge, SA Teichmann - Nature communications, 2020 - nature.com
Single cell transcriptomics technologies have vast potential in advancing our understanding
of biology and disease. Here, Sarah Aldridge and Sarah Teichmann review the last decade …

Single-cell genomics meets human genetics

ASE Cuomo, A Nathan, S Raychaudhuri… - Nature Reviews …, 2023 - nature.com
Single-cell genomic technologies are revealing the cellular composition, identities and
states in tissues at unprecedented resolution. They have now scaled to the point that it is …

Single-cell sequencing-based technologies will revolutionize whole-organism science

E Shapiro, T Biezuner, S Linnarsson - Nature Reviews Genetics, 2013 - nature.com
The unabated progress in next-generation sequencing technologies is fostering a wave of
new genomics, epigenomics, transcriptomics and proteomics technologies. These …

Single-cell genomics: coming of age

S Linnarsson, SA Teichmann - Genome biology, 2016 - Springer
Single-cell genomics is the study of the individuality of cells using omics approaches.
Although young, the field has now entered its teenage years and is beginning to show clear …

Dissecting genomic diversity, one cell at a time

PC Blainey, SR Quake - Nature methods, 2014 - nature.com
Dissecting genomic diversity, one cell at a time | Nature Methods Skip to main content Thank
you for visiting nature.com. You are using a browser version with limited support for CSS. To …

Single-cell sequencing technologies: current and future

J Liang, W Cai, Z Sun - Journal of Genetics and Genomics, 2014 - Elsevier
Intensively developed in the last few years, single-cell sequencing technologies now
present numerous advantages over traditional sequencing methods for solving the problems …

Challenges and emerging directions in single-cell analysis

GC Yuan, L Cai, M Elowitz, T Enver, G Fan, G Guo… - Genome biology, 2017 - Springer
Single-cell analysis is a rapidly evolving approach to characterize genome-scale molecular
information at the individual cell level. Development of single-cell technologies and …

Applications of single-cell DNA sequencing

GD Evrony, AG Hinch, C Luo - Annual review of genomics and …, 2021 - annualreviews.org
Over the past decade, genomic analyses of single cells—the fundamental units of life—have
become possible. Single-cell DNA sequencing has shed light on biological questions that …

[HTML][HTML] Single-cell transcriptome sequencing: recent advances and remaining challenges

S Liu, C Trapnell - F1000Research, 2016 - ncbi.nlm.nih.gov
Single-cell RNA-sequencing methods are now robust and economically practical and are
becoming a powerful tool for high-throughput, high-resolution transcriptomic analysis of cell …