Antagonists of N-methyl-D-aspartate receptors (NMDAR) have psychotomimetic effects in
humans and are used to model schizophrenia in animals. We used high-density …

N-methyl-d-aspartic acid (NMDA) receptors are critical for both normal brain functions and
the pathogenesis of schizophrenia. We investigated the functional changes of glutamatergic …

The NMDA receptor (NMDAr) hypofunction theory of schizophrenia suggests that aberrant
signaling through NMDAr underlies the pathophysiology of this disease. This is commonly …

Cognitive deficits associated with frontal lobe dysfunction are a determinant of long-term
disability in schizophrenia and are not effectively treated with available medications. Clinical …

Acute administration of N-methyl-D-aspartate receptor (NMDAR) antagonists in healthy
humans and animals produces working memory deficits similar to those observed in …

We employed multi-electrode array recording to evaluate the influence of NMDA receptors
(NMDAR) on spike-timing dynamics in prefrontal networks of monkeys as they performed a …

Cognitive deficits in schizophrenia, which include impairments in working memory and
attention, represent some of the most disabling symptoms of this complex psychiatric …

Non-competitive N-methyl-d-aspartate receptor antagonists mimic schizophrenia symptoms
and produce immediate and persistent antidepressant effects. We investigated the effects of …

Work on schizophrenia demonstrates the involvement of the hippocampus in the disease
and points specifically to hyperactivity of CA1. Many symptoms of schizophrenia can be …

NMDA receptors mediate excitatory postsynaptic potentials throughout the brain but,
paradoxically, NMDA receptor antagonists produce cortical excitation in humans and …