During development, cardiogenesis is orchestrated by a family of heart progenitors that build
distinct regions of the heart. Each region contains diverse cell types that assemble to form …

Regeneration or replacement of lost cardiomyocytes within the heart has the potential to
revolutionize cardiovascular medicine. Numerous methodologies have been used to …

Strategies for harnessing stem cells as a source to treat cell loss in heart disease are the
subject of intense research. Human pluripotent stem cells (hPSCs) can be expanded …

Human pluripotent stem cells can now be routinely differentiated into cardiac cell types
including contractile cardiomyocytes, enabling the study of heart development and disease …

Maturation is the last phase of heart development that prepares the organ for strong,
efficient, and persistent pumping throughout the mammal's lifespan. This process is …

Ischemic heart disease remains one of the most prominent causes of mortalities worldwide
with heart transplantation being the gold-standard treatment option. However, due to the …

The cardiomyocyte (CM) subtypes in the mammalian heart derive from distinct lineages
known as the first heart field (FHF), the anterior second heart field (aSHF), and the posterior …

Developmental biologists have uncovered many of the signaling proteins that are required
to recruit early embryonic cells to the myocardial lineage. A detailed understanding of their …

The heart is the first organ to form during embryonic development. Given the complex nature
of cardiac differentiation and morphogenesis, it is not surprising that some form of congenital …

Since human embryonic stem cells were first differentiated to beating cardiomyocytes a
decade ago, interest in their potential applications has increased exponentially. This has …