Several experimental and clinical studies reported that hyperuricemia may trigger
hypertension, metabolic syndrome, vascular damage and renal disease. Furthermore, a …

Uric acid is the end product of purine metabolism. Its immediate precursor, xanthine, is
converted to uric acid by an enzymatic reaction involving xanthine oxidoreductase. Uric acid …

Hyperuricemia, which has been considered as a cause of gout and nephrolithiasis has
recently been suggested to be associated with hypertension, coronary heart disease, heart …

Hyperuricemia is a frequent finding in diseases in which the clinical manifestations are
thought to be secondary to a state of generalized vascular endothelial dysfunction and …

Hyperuricemia is known to be associated with the presence of cardiovascular and metabolic
syndrome and with the development of incipient kidney disease and an accelerated renal …

Uric acid is an intermediate product formed from the metabolism of purine. The high serum
uric acid level is termed as hyperuricemia. Gout, a metabolic disorder is associated with high …

Hyperuricemia is caused by reduced renal/extrarenal excretion and overproduction of uric
acid. It is affected by genetic predisposition related to uric acid transporters and by visceral …

Uric acid is the end product of purine metabolism catalyzed by xanthine oxidase in humans.
In the process of purine metabolism, reactive oxygen species, including superoxide, are …

Elevated levels of serum uric acid have been demonstrated to be closely related to the
development of cardiovascular, metabolic and renal disease. The mechanism responsible …

Purine metabolism in the circulatory system yields uric acid as its final oxidation product,
which is believed to be linked to the development of gout and kidney stones. Hyperuricemia …