Antibiotic resistance is one of the most significant challenges facing global healthcare. Since
the 1940s, antibiotics have been used to fight infections, initially with penicillin and …

The β-lactam antibiotics are essential for the treatment of a wide range of human bacterial
diseases. However, a class of zinc-dependent hydrolases known as the metallo-β …

Multidrug-resistant bacterial infections have become in recent years an increasingly
worrisome problem in the medical community. The β-lactams are the most used antibiotics …

The ability to produce ß-lactamase enzymes is the major cause of the resistance of bacteria
to ß-lactam antibiotics. These enzymes catalyze hydrolysis of four-membered ß-lactam rings …

Metallo-β-lactamases are the latest resistance mechanism of pathogenic and opportunistic
bacteria against carbapenems, considered as last resort drugs. The worldwide spread of …

Abstract Metallo‐β‐lactamases (MBLs) are zinc‐dependent bacterial enzymes that
inactivate essentially all classes of β‐lactam antibiotics including last‐resort carbapenems …

β‐Lactam antibiotics are the most commonly used antibacterial agents and growing
resistance to these drugs is a concern. Metallo‐β‐lactamases are a diverse set of enzymes …

Antibiotic resistance & metallo-β-lactamases: a current global issue β-lactams, such as
penicillins, cephalosporins and carbapenems, are currently the most frequently prescribed …

Modern medicine is threatened by the global rise of antibiotic resistance, especially among
Gram-negative bacteria. Metallo-β-lactamase (MBL) enzymes are a particular concern and …

Resistance to β‐lactam antibacterials is commonly associated with the production of the
serine β‐lactamases (SBLs) and/or metallo‐β‐lactamases (MBLs). Although clinically useful …