Purpose Deposition of drug emitted from two commercially available inhalers was measured
in an in vitro child oral airway model and compared to existing in vivo data to examine the …

Background: The development of accurate in vitro—in vivo correlations requires the
consideration of a number of factors in vitro, including the emulation of upper airway …

Background: In vitro–in vivo correlations (IVIVCs) are needed to relate in vitro test results for
deposition to mean data from clinical trials, as well as the extremes in a population. Because …

Infants and children constitute a patient group that has unique requirements in pulmonary
drug delivery. Since their lungs develop continuously until they reach adulthood, the airways …

Respiratory tract deposition models provide a useful method for optimizing the design and
administration of inhaled pharmaceutical aerosols, and can be useful for estimating …

Background: In vitro—in vivo correlations (IVIVC) for lung deposition may be established by
testing inhalers in vitro with realistic mouth–throat (MT) models and inhalation profiles (IP) …

In vitro polydisperse aerosol deposition in three mouth–throat models, namely, the USP
(United States Pharmacopeia) mouth–throat (induction port), idealized mouth–throat, and …

Purpose To quantify distribution of albuterol aerosol generated by a pneumatic nebulizer
within the nose and lungs of a model of a 9-month-old child (SAINT) and aerosol loss to the …

Background: A new in vitro test method for dry powder inhalers (DPIs) was recently found to
be predictive of the published in vivo results for Budelin Novolizer. The present study was …

Introduction: Aerosol drug delivery to the lungs via inhalation is widely used in the treatment
of respiratory diseases. The deposition pattern of inhaled particles within the airways of the …