[HTML][HTML] Dynamic transcription of distinct classes of endogenous retroviral elements marks specific populations of early human embryonic cells
About half of the human genome consists of highly repetitive elements, most of which are
considered dispensable for human life. Here, we report that repetitive elements originating …
considered dispensable for human life. Here, we report that repetitive elements originating …
Decoding the regulatory network of early blood development from single-cell gene expression measurements
V Moignard, S Woodhouse, L Haghverdi, AJ Lilly… - Nature …, 2015 - nature.com
Reconstruction of the molecular pathways controlling organ development has been
hampered by a lack of methods to resolve embryonic progenitor cells. Here we describe a …
hampered by a lack of methods to resolve embryonic progenitor cells. Here we describe a …
[HTML][HTML] Single-cell transcriptome analyses reveal signals to activate dormant neural stem cells
Y Luo, V Coskun, A Liang, J Yu, L Cheng, W Ge, Z Shi… - Cell, 2015 - cell.com
The scarcity of tissue-specific stem cells and the complexity of their surrounding environment
have made molecular characterization of these cells particularly challenging. Through single …
have made molecular characterization of these cells particularly challenging. Through single …
Single-cell analysis in cancer genomics
Genetic changes and environmental differences result in cellular heterogeneity among
cancer cells within the same tumor, thereby complicating treatment outcomes. Recent …
cancer cells within the same tumor, thereby complicating treatment outcomes. Recent …
[HTML][HTML] Deep sequencing and de novo assembly of the mouse oocyte transcriptome define the contribution of transcription to the DNA methylation landscape
Background Previously, a role was demonstrated for transcription in the acquisition of DNA
methylation at imprinted control regions in oocytes. Definition of the oocyte DNA methylome …
methylation at imprinted control regions in oocytes. Definition of the oocyte DNA methylome …
[HTML][HTML] Histone demethylase expression enhances human somatic cell nuclear transfer efficiency and promotes derivation of pluripotent stem cells
The extremely low efficiency of human embryonic stem cell (hESC) derivation using somatic
cell nuclear transfer (SCNT) limits its potential application. Blastocyst formation from human …
cell nuclear transfer (SCNT) limits its potential application. Blastocyst formation from human …
[HTML][HTML] Prediction model for aneuploidy in early human embryo development revealed by single-cell analysis
M Vera-Rodriguez, SL Chavez, C Rubio… - Nature …, 2015 - nature.com
Aneuploidies are prevalent in the human embryo and impair proper development, leading to
cell cycle arrest. Recent advances in imaging and molecular and genetic analyses are …
cell cycle arrest. Recent advances in imaging and molecular and genetic analyses are …
The first murine zygotic transcription is promiscuous and uncoupled from splicing and 3′ processing
K Abe, R Yamamoto, V Franke, M Cao, Y Suzuki… - The EMBO …, 2015 - embopress.org
Initiation of zygotic transcription in mammals is poorly understood. In mice, zygotic
transcription is first detected shortly after pronucleus formation in 1‐cell embryos, but the …
transcription is first detected shortly after pronucleus formation in 1‐cell embryos, but the …
Sculpting the transcriptome during the oocyte-to-embryo transition in mouse
In mouse, the oocyte-to-embryo transition entails converting a highly differentiated oocyte to
totipotent blastomeres. This transition is driven by degradation of maternal mRNAs, which …
totipotent blastomeres. This transition is driven by degradation of maternal mRNAs, which …
[HTML][HTML] Single cell transcriptomics: methods and applications
Traditionally, gene expression measurements were performed on “bulk” samples containing
populations of thousands of cells. Recent advances in genomic technology have made it …
populations of thousands of cells. Recent advances in genomic technology have made it …