Background Pulmonary pleomorphic carcinoma (PPC) follows an aggressive clinical course
and outcomes are disappointing. Due to its rarity, however, the clinicopathological and …

Epiregulin (EREG) belongs to the ErbB family of ligands. EREG binds to EGFR and ErbB4
receptor and stimulates homodimers of EGFR and ErbB4 in addition to all possible …

Journal of Thoracic Oncology®• Volume 10, Number 4, April 2015 Editorial to the Japanese
study, only one case showed progressive disease. Also, in a recent study by Ali et al., 11 two …

Background The identification of ALK and ROS1 rearrangements and the availability of an
effective target therapy, such as crizotinib, represent a new option in the treatment of …

© Translational lung cancer research. All rights reserved. Transl Lung Cancer Res 2015; 4
(5): 639-641 www. tlcr. org 4.1 months (median of six cycles of chemotherapy started) for the …

Highly tumorigenic stem-like cells, considered tumor-initiating cells (TICs), are the main
cause of lung cancer initiation, relapse, and drug resistance. In this study, we identified that …

The treatment of patients with advanced non-small-cell lung cancer harboring chromosomal
rearrangements of anaplastic lymphoma kinase (ALK) has been revolutionized by the …

Although the incidence of lung cancer has decreased due to the reduction of tobacco use,
lung cancer remains the leading cause of cancer-related death. Lung squamous cell …

Infectious complications are a major cause of morbidity and mortality in patients with hemato-
oncological diseases. Although disease-related immunosuppression represents one factor …

Background There have been conflicting findings regarding the efficacy of pemetrexed for
lung cancer with anaplastic lymphoma kinase (ALK) rearrangement. This study was …