Antimicrobial and Anti-inflammatory Activities and Mechanism of Action of Cathelicidin-derived Synthetic Antimicrobial Peptides

자콥, 비누 - 2015 - oak.chosun.ac.kr
ABSTRACT Antimicrobial and Anti-inflammatory Activities and Mechanism of Action of
Cathelicidin-derived Synthetic Antimicrobial Peptides Binu Jacob Advisor: Prof. Song Yub …

Short KR‐12 analogs designed from human cathelicidin LL‐37 possessing both antimicrobial and antiendotoxic activities without mammalian cell toxicity

B Jacob, IS Park, JK Bang… - Journal of peptide science, 2013 - Wiley Online Library
KR‐12 (residues 18–29 of LL‐37) was known to be the smallest peptide of human
cathelicidin LL‐37 possessing antimicrobial activity. In order to optimize α‐helical short …

Augmentation of the bactericidal activities of human cathelicidin CAP18/LL-37-derived antimicrobial peptides by amino acid substitutions

I Nagaoka, K Kuwahara-Arai, H Tamura… - Inflammation …, 2005 - Springer
Objective: Mammalian myeloid and epithelial cells express various peptide antibiotics (such
as defensins and cathelicidins) that contribute to the innate host defense against invading …

Bacterial killing mechanism of sheep myeloid antimicrobial peptide-18 (SMAP-18) and its Trp-substituted analog with improved cell selectivity and reduced …

B Jacob, Y Kim, JK Hyun, IS Park, JK Bang, SY Shin - Amino Acids, 2014 - Springer
To develop short antimicrobial peptide with improved cell selectivity and reduced
mammalian cell toxicity compared to sheep myeloid antimicrobial peptide-29 (SMAP-29) …

Analogs of the cathelicidin-derived antimicrobial peptide PMAP-23 exhibit improved stability and antibacterial activity

Y Liu, T Shen, L Chen, J Zhou, C Wang - Probiotics and antimicrobial …, 2021 - Springer
Antimicrobial peptides (AMPs) have gained interesting as a new type of antimicrobial agent.
The cathelicidin-derived antimicrobial peptide PMAP-23 has broad-spectrum antibacterial …

LL-37-derived short antimicrobial peptide KR-12-a5 and its d-amino acid substituted analogs with cell selectivity, anti-biofilm activity, synergistic effect with …

EY Kim, G Rajasekaran, SY Shin - European journal of medicinal chemistry, 2017 - Elsevier
Abstract KR-12-a5 is a 12-meric α-helical antimicrobial peptide (AMP) with dual
antimicrobial and anti-inflammatory activities designed from human cathelicidin LL-37. We …

Design, synthesis, and characterization of non-hemolytic antimicrobial peptides related to human cathelicidin LL-37

R Krishnamoorthy, P Adhikari, P Anaikutti - RSC advances, 2023 - pubs.rsc.org
We designed and synthesised the N-terminally labeled cationic and hydrophobic peptides,
ie, FFKKSKEKIGKEFKKIVQKI (P1) and FRRSRERIGREFRRIVQRI (P2) related to the human …

The stereochemical effect of SMAP-29 and SMAP-18 on bacterial selectivity, membrane interaction and anti-inflammatory activity

B Jacob, G Rajasekaran, EY Kim, IS Park, JK Bang… - Amino Acids, 2016 - Springer
Sheep myeloid antimicrobial peptide-29 (SMAP-29) is a cathelicidin-related antimicrobial
peptide derived from sheep myeloid cells. In order to investigate the effects of l-to-d-amino …

Design, synthesis and mechanism of action of novel host defense peptides and peptidomimetics with antimicrobial, and anti-inflammatory activities

김은영 - 2021 - oak.chosun.ac.kr
Part. 1 KR-12-a5 is a 12-meric-helical antimicrobial peptide (AMP) with dual antimicrobial
and anti-inflammatory activities designed from human cathelicidin LL-37. We designed and …

Augmentation of the lipopolysaccharide-neutralizing activities of human cathelicidin CAP18/LL-37-derived antimicrobial peptides by replacement with hydrophobic …

I Nagaoka, S Hirota, F Niyonsaba… - Clinical and Vaccine …, 2002 - Am Soc Microbiol
Mammalian myeloid and epithelial cells express various peptide antibiotics (such as
defensins and cathelicidins) that contribute to the innate host defense against invading …