Blood platelets prevent bleeding after trauma by forming occlusive aggregates at sites of
vascular injury. Platelet aggregation is mediated by the integrin heterodimer αIIbβ3 and …

This study demonstrates that two orthogonal events regulate integrin αIIbβ3's interactions
with fibrinogen, its primary physiological ligand:(1) conformational changes at the αIIb− β3 …

Platelet integrins α2β1 and αIIbβ3 play critical roles in platelet adhesion and thrombus
formation after vascular injury. On resting platelets, both integrins are in a low-affinity state …

Integrin α IIb β 3 plays a critical role in platelet aggregation, a central response in
hemostasis and thrombosis. This function of α IIb β 3 depends upon a transition from a …

Platelets are critical for the maintenance of the integrity of the vascular system and are the
first line of defence against haemorrhage. When they encounter a subendothelial matrix …

Platelet aggregation is not only an essential part of hemostasis, but also initiates acute
coronary syndrome or ischemic stroke. The precise understanding of the activation …

Agonist-generated inside-out signals enable the platelet integrin α IIb β 3 to bind soluble
ligands such as fibrinogen. We found that inhibiting actin polymerization in unstimulated …

Heterodimeric receptors of the β1 and β3 integrin families mediate platelet adhesion and
aggregation in hemostasis and thrombosis. In resting platelets, integrins are expressed in a …

Integrin αIIbβ3 is a member of the integrin family of transmembrane proteins present on the
plasma membrane of platelets. Integrin αIIbβ3 is widely known to regulate the process of …

Integrins are a ubiquitous family of non‐covalently associated α/β transmembrane
heterodimers linking extracellular ligands to intracellular signaling pathways [1][Cell, 2002; …