ALC1, also known as CHD1L, was originally identified as a gene present on a human
chromosome 1q21 region amplified in~ 50% of human hepatocellular carcinomas (HCC) …

The human ALC1/CHD1L oncogene encodes an SNF2 family ATPase with a macrodomain
that binds poly (ADP-ribose)(PAR). We and others previously showed that ALC1 possesses …

Regulation of ALC1 (Amplified in Liver Cancer) involves interplay between the SNF2
ATPase domain, PAR binding macrodomain and other conserved elements Rushi D …

The SNF2 family ATPase Amplified in Liver Cancer 1 (ALC1) is the only chromatin
remodeling enzyme with a poly (ADP-ribose)(PAR) binding macrodomain. ALC1 functions …

ALC1, also known as CHD1L, is a macrodomain‐containing SNF2‐family ATPase that has
been implicated in various cancers and has apparent roles in DNA repair. ALC1 displays …

The human ALC1 (Amplified in Liver Cancer 1) gene was originally identified as a gene
present on a human chromosome 1q21 region amplified in a large fraction of hepatocellular …

Post-translational modifications play a key role in recruiting chromatin remodeling and
modifying enzymes to specific regions of chromosomes to modulate chromatin structure …

The genetic information of eukaryotic cells is packaged inside the nucleus as chromatin.
This packaging restricts access to the DNA and therefore represents a barrier for processes …

Posttranslational modifications play a key role in recruiting chromatin remodeling and
modifying enzymes to specific regions of chromosomes to modulate chromatin structure …

Upon DNA damage, the ALC1/CHD1L nucleosome remodeling enzyme (remodeler) is
activated by binding to poly (ADP-ribose). How activated ALC1 recognizes the nucleosome …