Despite the growing body of evidence pointing on the involvement of tissue non-specific
alkaline phosphatase (TNAP) in brain function and diseases like epilepsy and Alzheimer's …

To-date, the function of tissue-nonspecific alkaline phosphatase (TNAP) has largely been
defined through studies in patients and mice affected by hypophosphatasia (HPP), a rare …

Tissue-nonspecific alkaline phosphatase (TNAP) is one of the four isozymes in humans and
mice that have the capacity to hydrolyze phosphate groups from a wide spectrum of …

New evidences have been reported that point to the ecto-enzyme, tissue-nonspecific
alkaline phosphatase (TNAP), as a key element at the origin of two opposite phenomena …

Evidence is emerging with regard to the role of tissue non-specific alkaline phosphatase
(TNAP) in neural functions. As an ectophosphatase, this enzyme might influence neural …

The presence of alkaline phosphatase (AP) activity in the neural tissue has been described
decades ago. However, only recent studies clarified the isotype, regional distribution and …

Patients suffering from the rare hereditary disease hypophosphatasia (HPP), which is based
on mutations in the ALPL gene, tend to develop central nervous system (CNS) related …

Tissue-nonspecific alkaline phosphatase is expressed both in the developing and adult
mammalian brain. Expression is particularly strong in the developing nervous system and …

The tissue non-specific alkaline phosphatase (TNAP) is a glycosyl-phosphatidylinositol
(GPI) anchored glycoprotein which exists under different forms and is expressed in different …

Mutations in the tissue-nonspecific alkaline phosphatase (TNAP) gene can result in skeletal
and dental hypomineralization and severe neurological symptoms. TNAP is expressed in …