Targeted delivery of drugs to tumors is critical for optimal implementation of chemotherapy.
Targeted drug delivery can be achieved by encapsulating drugs in nanometer-sized drug …

Nanoparticles have been employed in cancer management as vectors to deliver
chemotherapeutic and/or imaging agents to tumors. Enhanced tumor accumulation occurs …

Poor penetration of anticancer drags into solid tumors significantly limits their efficacy. This
phenomenon has long been observed for small-molecule chemotherapeutics, and it can be …

The effective treatment of patients with cancer hinges on the delivery of therapeutics to a
tumor site. Nanoparticles provide an essential transport system. We present 5 principles to …

Elevated interstitial fluid pressure and solid stress within tumors contribute to poor
intratumoral distribution of nanomedicine. In this study, we hypothesized that the presence of …

Despite their great promise, only a few nanoparticle formulations have been approved for
clinical use in oncology. The failure of nano-scale drugs to enhance cancer therapy is in …

Nanoparticles have been explored as a promising drug carrier for chemotherapy, with
several systems in various stages of commercial development. This chapter describes …

Although the pharmaceutical industry has been successful in discovering many new
cytotoxic drugs that are potential candidates for cancer treatment, cancer remains a leading …

Nanotherapeutics have improved the quality of life of cancer patients, primarily by reducing
the adverse effects of chemotherapeutic agents, but improvements in overall survival are …

After the discovery of the enhanced permeability and retention effect in 1986, it was
envisioned that nanoparticle-mediated tumor-targeted delivery of chemotherapeutics would …