The role of PPAR-gamma receptor in pruritus

S Ostadhadi, V Nikoui, A Haj-Mirzaian… - European Journal of …, 2015 - Elsevier
Recent studies have clarified the novel mediators and neuronal pathways involved in itch
transmission, which might result in introduction of new therapies for management of pruritus …

Pathophysiology of pruritus in atopic dermatitis: an overview

S Ständer, M Steinhoff - Experimental dermatology, 2002 - Wiley Online Library
Pruritus is an essential feature of atopic dermatitis (AD) and the diagnosis of active AD
cannot be made without the history of itching. Because of the high impact on life quality …

Molecular and cellular mechanisms of itch in psoriasis

E Komiya, M Tominaga, Y Kamata, Y Suga… - International Journal of …, 2020 - mdpi.com
Itch (or pruritus) was not previously recognized as a serious symptom of psoriasis. However,
approximately 60–90% of psoriatic patients with pruritus have stated that it deteriorates their …

Pruritus: a sensory symptom generated in cutaneous immuno-neuronal crosstalk

AG Szöllősi, A Oláh, E Lisztes, Z Griger… - Frontiers in …, 2022 - frontiersin.org
Pruritus or itch generated in the skin is one of the most widespread symptoms associated
with various dermatological and systemic (immunological) conditions. Although many details …

Mediators of chronic pruritus in atopic dermatitis: getting the itch out?

NK Mollanazar, PK Smith, G Yosipovitch - Clinical reviews in allergy & …, 2016 - Springer
For centuries, itch was categorized as a submodality of pain. Recent research over the last
decade has led to the realization that itch is in fact a separate and distinct, albeit closely …

Mediators of pruritus in psoriasis

A Reich, JC Szepietowski - Mediators of inflammation, 2007 - Wiley Online Library
The pathogenesis of pruritus in psoriasis remains unclear. Many possible mediators were
implicated to transmit or modulate this sensation in psoriasis, but none has been clearly …

Molecular mechanisms of pruritus

J Meng, M Steinhoff - Current research in translational medicine, 2016 - Elsevier
Pruritus is an unpleasant sensation that evokes the urgent desire to scratch. It is a symptom
derived from many nervous system disorders that affects a large population of humans and …

[HTML][HTML] Understanding itch: an update on mediators and mechanisms of pruritus

I Hassan, MLI Haji - Indian journal of dermatology, venereology and …, 2014 - ijdvl.com
Pruritus is the most common symptom secondary to skin diseases. Advances in the fields of
neurobiology, immunology and physiology have made it possible for us to understand and …

How best to fight that nasty itch–from new insights into the neuroimmunological, neuroendocrine, and neurophysiological bases of pruritus to novel therapeutic …

T Bíró, MC Ko, B Bromm, ET Wei… - Experimental …, 2005 - Wiley Online Library
While the enormous clinical and psychosocial importance of pruritus in many areas of
medicine and the detrimental effects of chronic 'itch'on the quality of life of an affected …

Neurophysiology of pruritus: cutaneous elicitation of itch

S Ständer, M Steinhoff, M Schmelz… - Archives of …, 2003 - jamanetwork.com
Itching is defined as an unpleasant cutaneous sensation leading to the desire to scratch. It
serves as a physiological self-protective mechanism as do other cutaneous sensations like …