Biological underpinnings of trauma and post-traumatic stress disorder: focusing on genetics and epigenetics

J Ryan, I Chaudieu, ML Ancelin, R Saffery - Epigenomics, 2016 - Taylor & Francis
Certain individuals are more susceptible to stress and trauma, as well as the physical and
mental health consequences following such exposure, including risk for post-traumatic …

Early origins of mental disorder-risk factors in the perinatal and infant period

L Newman, F Judd, CA Olsson, D Castle, C Bousman… - BMC psychiatry, 2016 - Springer
Background There is increasing understanding of the significance of early
neurodevelopment in establishing risk for the range of mental disorders. Models of the early …

Deficient inhibitory control as an outcome of childhood trauma

DF Marshall, AM Passarotti, KA Ryan, M Kamali… - Psychiatry …, 2016 - Elsevier
Childhood trauma has been linked to the development and severity of psychiatric disorders
as well as deficits in cognitive functioning. This study aimed to investigate the performance …

The effects of a probiotic formulation (Lactobacillus rhamnosus and L. helveticus) on developmental trajectories of emotional learning in stressed infant rats

CSM Cowan, BL Callaghan, R Richardson - Translational psychiatry, 2016 - nature.com
Recently, scientific interest in the brain–gut axis has grown dramatically, particularly with
respect to the link between gastrointestinal and psychiatric dysfunction. However, the role of …

Early childhood environment and genetic interactions: the diathesis for suicidal behavior

BS Brodsky - Current psychiatry reports, 2016 - Springer
Adverse childhood experiences are associated with higher risk for suicide and suicidal
behavior later in life. There are known associations between childhood trauma, particularly …

Stress-related immune markers in depression: implications for treatment

MM Hughes, TJ Connor, A Harkin - International Journal of …, 2016 - academic.oup.com
Major depression is a serious psychiatric disorder; however, the precise biological basis of
depression still remains elusive. A large body of evidence implicates a dysregulated …

In search of the HPA axis activity in unipolar depression patients with childhood trauma: Combined cortisol awakening response and dexamethasone suppression test

S Lu, W Gao, M Huang, L Li, Y Xu - Journal of psychiatric research, 2016 - Elsevier
The aim of the present study was to examine the impact of childhood trauma on HPA axis
activity both in depression patients and healthy controls in order to determine the role of …

Epigenetic basis of sensitization to stress, affective episodes, and stimulants: implications for illness progression and prevention

RM Post - Bipolar disorders, 2016 - Wiley Online Library
Objectives The process of sensitization (increased responsivity) to the recurrence of
stressors, affective episodes, and bouts of substance abuse that can drive illness …

Association between preoperative depression and long-term survival following coronary artery bypass surgery—a systematic review and meta-analysis

M Stenman, MJ Holzmann, U Sartipy - International Journal of Cardiology, 2016 - Elsevier
Background Depression is common in patients with cardiovascular disease. The importance
of preoperative depression for long-term survival following coronary artery bypass grafting …

Blocking glucocorticoid receptors at adolescent age prevents enhanced freezing between repeated cue-exposures after conditioned fear in adult mice raised under …

JM Arp, JP Ter Horst, M Loi, J den Blaauwen… - … of Learning and …, 2016 - Elsevier
Early life adversity can have long-lasting impact on learning and memory processes and
increase the risk to develop stress-related psychopathologies later in life. In this study we …