High blood pressure is a major risk factor for cardiovascular disease and premature death.
However, there is limited knowledge on specific causal genes and pathways. To better …

We characterized DNA methylation quantitative trait loci (mQTLs) in a large collection (n=
166) of human fetal brain samples spanning 56–166 d post-conception, identifying> 16,000 …

Understanding the genetic architecture of gene expression traits is key to elucidating the
underlying mechanisms of complex traits. Here, for the first time, we perform a systematic …

Genome-wide association studies (GWAS) have identified hundreds of genetic variants
associated with complex traits and diseases. However, elucidating the causal genes …

Osteoporosis is characterized by low bone mass and an increased risk of fracture. Genetic
factors, environmental factors and gene–environment interactions all contribute to a person's …

Genome-wide association studies (GWAS) have transformed our understanding of the
genetics of complex traits such as autoimmune diseases, but how risk variants contribute to …

Background Although genome-wide association studies (GWAS) have identified over 100
genetic loci associated with rheumatoid arthritis (RA), our ability to translate these results …

To gain biological insight into the discoveries made by GWAS and meta-analysis studies,
effective integration of functional data generated by large-scale efforts such as the GTEx …

Expression quantitative trait locus (eQTL) mapping provides a powerful means to identify
functional variants influencing gene expression and disease pathogenesis. We report the …

Genome-wide association studies (GWAS) have remarkably advanced insight into the
genetic basis of schizophrenia (SCZ). Still, most of the functional variance in disease risk …