In this issue of Structure, Bolten et al.(2016) describe the organization of the mycobacterial
proteasome in complex with the ATP-independent bacterial proteasome activator (Bpa …

The occurrence of the proteasome in bacteria is limited to the phylum of actinobacteria,
where it is maintained in parallel to the usual bacterial compartmentalizing proteases. The …

In all domains of life, proteasomes are gated chambered proteases that require opening by
activators in order to facilitate protein degradation. Twelve proteasome accessory factor E …

Protein degradation, which occurs in all cells, is essential for proper cellular function by
regulating many cellular processes, destroying misfolded proteins, and providing protein …

The human pathogen Mycobacterium tuberculosis (Mtb) requires a proteasome system to
cause lethal infections in mice. We recently found that proteasome accessory factor E (PafE …

Interest in bacterial proteasomes was sparked by the discovery that proteasomal
degradation is required for the pathogenesis of Mycobacterium tuberculosis, one of the …

Efficient proteasomal degradation requires the orchestrated execution of multiple activities
within the proteasome regulatory complex, including substrate binding, unfolding, gate …

In all domains of life, proteasomes are gated, chambered proteases that require opening by
activators to facilitate protein degradation. Twelve proteasome accessory factor E (PafE) …

Formation of the eukaryotic proteasome is not a spontaneous process but a highly ordered
process assisted by several assembly chaperones. In contrast, archaeal proteasome …

Mycobacterium tuberculosis harbors proteasomes that recruit substrates for degradation
through an ubiquitin-like modification pathway. Recently, a non-ATPase activator termed …