Objective A challenge in studying human salivary glands is to maintain the cells ex vivo in
their three‐dimensional (3D) morphology with an intact native extracellular matrix (ECM) …

Saliva aids in digestion, lubrication, and protection of the oral cavity against dental caries
and oropharyngeal infections. Reduced salivary secretion, below an adequate level to …

The salivary glands produce saliva and are important in maintaining oral health. Saliva
keeps the mouth moist, cleanses the oral cavity, aids digestion, and has antibacterial …

This study aimed to achieve functional reconstitution of salivary units from human salivary
gland cells in an in vitro three-dimensional culture system. Human salivary cells were …

Freshly isolated salivary cells can be plated on an extracellular matrix, such as growth factor‐
reduced Matrigel (GFR‐MG), to induce the formation of three‐dimensional (3D) structures …

Objective: Development of an artificial salivary gland will benefit patients with xerostomia
after radiation therapy for upper respiratory cancer. The goal is to devise a three …

The salivary glands are a site of significant interest for researchers interested in multiple
aspects of human disease. One goal of researchers is to restore function of glands damaged …

The use of polarized salivary gland cell monolayers has contributed to our understanding of
salivary gland physiology. However, these cell models are not representative of glandular …

Oral mucosa and salivary gland are composed of complex and dynamic networks of
extracellular matrix, multiple cell types, vasculature, and various biochemical agents. Two …

Applying tissue engineering principles to design an auto‐secretory device is a potential
solution for patients suffering loss of salivary gland function. However, the largest challenge …