Stability analysis of closed-loop anaesthesia system with nonlinear uncertainty: A circle criterion approach
Inter-individual variability is one of the major challenge in closed-loop control of
anaesthesia. This variability could lead to stability problem and must be taken into account …
anaesthesia. This variability could lead to stability problem and must be taken into account …
Nonlinear stability analysis of anaesthesia control system using circle criterion
Stability analysis of the anaesthesia control systems due to system nonlinearity has not been
well studied in the literature. This paper studies the sufficient conditions for absolute stability …
well studied in the literature. This paper studies the sufficient conditions for absolute stability …
Design of depth of anesthesia controllers in the presence of model uncertainty
A major obstacle in the design of controllers to regulate the depth of anesthesia (DoA)
consists in the high model uncertainty due to inter-patient variability. Surprisingly, the use of …
consists in the high model uncertainty due to inter-patient variability. Surprisingly, the use of …
Patient variability and uncertainty quantification in anesthesia: part ii–pkpd uncertainty
S Bibian, GA Dumont, M Huzmezan, CR Ries - IFAC Proceedings volumes, 2006 - Elsevier
The outcome of any surgery is particularly dependent on the adequate delivery of anesthetic
drugs. Not surprisingly clinical researchers have been trying to automatize their delivery in …
drugs. Not surprisingly clinical researchers have been trying to automatize their delivery in …
Quantifying uncertainty bounds in anesthetic PKPD models
S Bibian, GA Dumont, M Huzmezan… - The 26th Annual …, 2004 - ieeexplore.ieee.org
A major challenge faced when designing controllers to automate anesthetic drug delivery is
the large variability that exists between and within patients. This intra-and inter-patient …
the large variability that exists between and within patients. This intra-and inter-patient …
Quantifying additive uncertainty in an identified multivariable model for closed loop control of depth of anesthesia
General anaesthesia is characterized by unconsciousness through the action of hypnotics,
and by loss of the ability to perceive pain through the action of analgesics. Because most …
and by loss of the ability to perceive pain through the action of analgesics. Because most …
Patient variability and uncertainty quantification in anesthesia: part i–pkpd modeling and identification
S Bibian, GA Dumont, M Huzmezan, CR Ries - IFAC Proceedings volumes, 2006 - Elsevier
The outcome of any surgery is particularly dependent on the adequate delivery of anesthetic
drugs. Not surprisingly clinical researchers have been trying to automatize their delivery in …
drugs. Not surprisingly clinical researchers have been trying to automatize their delivery in …
Nonlinear dynamics in closed-loop anesthesia: Pharmacokinetic/pharmacodynamic model under pid-feedback
ZT Zhusubaliyev, A Medvedev… - 2014 American Control …, 2014 - ieeexplore.ieee.org
The problem of finding admissible tunings for a PID-controller for automatic neuromuscular
blockade drug administration in closed-loop anesthesia is considered. A conventional …
blockade drug administration in closed-loop anesthesia is considered. A conventional …
Depth of anesthesia control using internal model control techniques
S Anna, P Wen - IEEE/ICME International Conference on …, 2010 - ieeexplore.ieee.org
The major difficulty in the design of closed-loop control during anaesthesia is the inherent
patient variability due to differences in demographic and drug tolerance. These …
patient variability due to differences in demographic and drug tolerance. These …
Positive interval observer-based state feedback controller for uncertain general anaesthesia system
The drug delivery process of general anaesthesia in the human body is most commonly
described by the Pharmacokinetic/Pharmacodynamic (PK/PD) model. Since the PK model is …
described by the Pharmacokinetic/Pharmacodynamic (PK/PD) model. Since the PK model is …