[HTML][HTML] RTS, S/AS01 malaria vaccine efficacy is not modified by seasonal precipitation: results from a phase 3 randomized controlled trial in Malawi

L Han, MG Hudgens, ME Emch, JJ Juliano, C Keeler… - Scientific Reports, 2017 - nature.com
Abstract The World Health Organization has selected Malawi as one of three sites to pilot the
roll-out of RTS, S/AS01 in phase 4 trials. As policy discussions for the expanded use of RTS …

[HTML][HTML] Dichotomous miR expression and immune responses following primary blood-stage malaria

JG Burel, SH Apte, PL Groves, MJ Boyle, C Langer… - JCI insight, 2017 - ncbi.nlm.nih.gov
Clinical responses to infection or vaccination and the development of effective immunity are
characterized in humans by a marked interindividual variability. To gain an insight into the …

[HTML][HTML] Longitudinal estimation of Plasmodium falciparum prevalence in relation to malaria prevention measures in six sub-Saharan African countries

C Drakeley, S Abdulla, ST Agnandji, JF Fernandes… - Malaria journal, 2017 - Springer
Abstract Background Plasmodium falciparum prevalence (Pf PR) is a widely used metric for
assessing malaria transmission intensity. This study was carried out concurrently with the …

[HTML][HTML] Presentation of life-threatening invasive nontyphoidal Salmonella disease in Malawian children: A prospective observational study

CA MacLennan, CL Msefula, EN Gondwe… - PLoS neglected …, 2017 - journals.plos.org
Nontyphoidal Salmonellae commonly cause invasive disease in African children that is often
fatal. The clinical diagnosis of these infections is hampered by the absence of a clear clinical …

[HTML][HTML] New gorilla adenovirus vaccine vectors induce potent immune responses and protection in a mouse malaria model

K Limbach, M Stefaniak, P Chen, NB Patterson, G Liao… - Malaria journal, 2017 - Springer
Abstract Background A DNA-human Ad5 (HuAd5) prime-boost malaria vaccine has been
shown to protect volunteers against a controlled human malaria infection. The potency of …

Ionic liquid mediated stereoselective synthesis of alanine linked hybrid quinazoline-4 (3H)-one derivatives perturbing the malarial reductase activity in folate pathway

TS Patel, JD Bhatt, SF Vanparia, UH Patel… - Bioorganic & medicinal …, 2017 - Elsevier
Grimmel's method was optimized as well as modified leading to the cyclization and
incorporation of alanine linked sulphonamide in 4-quinazolin-(3H)-ones. Further, the …

Towards functional antibody-based vaccines to prevent pre-erythrocytic malaria infection

B Sack, SHI Kappe, DN Sather - Expert Review of Vaccines, 2017 - Taylor & Francis
Introduction: An effective malaria vaccine would be considered a milestone of modern
medicine, yet has so far eluded research and development efforts. This can be attributed to …

Rapid assembly of the doubly-branched pentasaccharide domain of the immunoadjuvant jujuboside A via convergent B (C 6 F 5) 3-catalyzed glycosylation of …

RR Karimov, DS Tan, DY Gin - Chemical Communications, 2017 - pubs.rsc.org
A convergent synthesis of the complex, doubly-branched pentasaccharide domain of the
natural-product immunoadjuvant jujuboside A is described. The key step is a sterically …

Efficacy of Phase 3 Trial of RTS, S/AS01 Malaria Vaccine in infants: a systematic review and meta-analysis

S Mahmoudi, H Keshavarz - Hum. Vaccin. Immunother, 2017 - ncbi.nlm.nih.gov
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[HTML][HTML] Text recycling in health sciences research literature: a rhetorical perspective

C Moskovitz - Research integrity and peer review, 2017 - Springer
The past few years have seen a steady rise in the number of health science journals using
plagiarism detection software to screen submitted manuscripts. While there is widespread …