Spermatogenesis is crucial for male fertility and is therefore tightly controlled by a variety of
epigenetic regulators. However, the function of enhancer of zeste homolog 2 (EZH2) in …

Alterations to the gene encoding the EZH2 (KMT6A) methyltransferase, including both gain-
of-function and loss-of-function, have been linked to a variety of haematological …

As a model of “epigenetic catastrophe”, prostate cancer is driven by progressive epigenetic
changes that arise early in carcinogenesis and persist throughout disease progression. In …

EZH2 es una histona metiltransferasa que participa en la represión transcripcional de
numerosos genes implicados en cáncer mediante el silenciamiento de histonas. La …

How a single cell gives rise to multiple cell lineages is a central question in biology. The
processes that govern specification of cell identity occur mostly in the absence of …

Abstract Enhancer of Zeste 2 (Ezh2) mainly methylates lysine 27 of histone-H3 (H3K27me3)
as part of the Polycomb repressive complex 2 (PRC2) together with Suz12 and Eed …

Mammalian cell types and tissues have diverse functional roles within an organism but can
be derived by the differentiation of the embryonic stem cells (ESCs). ESCs are pluripotent …

Thymic epithelial cells (TEC) make up a majority of the thymic stroma and can be classified
into cortical (c) and medullary (m) compartment. TEC are responsible for generating a self …

La formation des trois feuillets embryonnaires primordiaux et leur régionalisation selon les
axes embryonnaires sont des étapes cruciales au cours du développement précoce. Dans …

Weaver syndrome (WS) is a rare overgrowth disorder characterized by tall stature,
macrocephaly, advanced bone age, facial dysmorphism, intellectual disability and cancer …