Metformin, a synthetic dimethyl biguanide, has been in clinical use for over 55 years, and
today is considered the first‐choice drug for the treatment of type 2 diabetes used by an …

Aging is now at the forefront of major challenges faced globally, creating an immediate need
for safe, widescale interventions to reduce the burden of chronic disease and extend human …

Although the geroprotectors discovery is a new biomedicine trend and more than 200
compounds can slow aging and increase the lifespan of the model organism, there are still …

Inhibitors of mTOR, including clinically available rapalogs such as rapamycin (Sirolimus)
and Everolimus, are gerosuppressants, which suppress cellular senescence. Rapamycin …

Abstract Fibroblast growth factor 21 (FGF21) has a significant role in the regulation of energy
metabolism, eg, in the control of systemic glucose and lipid metabolism. For instance, FGF21 …

Abstract Nuclear factor (erythroid-derived 2)-like 2 and its Caenorhabditis elegans ortholog,
SKN-1, are transcription factors that have a pivotal role in the oxidative stress response …

For many years metformin has been the gold standard in the treatment of type 2 diabetes.
According to recommendations of the most important diabetes associations, this is the first …

The target of rapamycin (TOR) pathway integrates signals from extracellular and intracellular
agents, such as growth factors, nutrients, mediators of energy balance, oxygen availability …

Metformin is an oral anti-diabetic used as first-line therapy for type 2 diabetes. Because
benefits of metformin extend beyond diabetes to other age-related pathology, and because …

Suicide remains a clear, present and increasing public health problem, despite being a
potentially preventable tragedy. Its incidence is particularly high in people with overt or un …