The replisome is a multiprotein molecular machinery responsible for the replication of DNA.
It is composed of several specialized proteins each with dedicated enzymatic activities, and …

Replisomes are the protein assemblies that replicate DNA. They function as molecular
motors to catalyze template-mediated polymerization of nucleotides, unwinding of DNA, the …

A complete understanding of the molecular mechanisms underlying the functioning of large,
multiprotein complexes requires experimental tools capable of simultaneously visualizing …

Replicative helicase and polymerase form the leading-strand replisome that unwinds
parental DNA and performs continuous leading-strand DNA synthesis. Uncoupling of the …

Replication of DNA plays a central role in transmitting hereditary information from cell to cell.
To achieve reliable DNA replication, multiple proteins form a stable complex, known as the …

The molecular machinery responsible for DNA replication, the replisome, must efficiently
coordinate DNA unwinding with priming and synthesis to complete duplication of both …

Helicases are molecular motors that translocate along single-stranded DNA and unwind
duplex DNA. They rely on the consumption of chemical energy from nucleotide hydrolysis to …

In all organisms, the protein machinery responsible for the replication of DNA, the replisome,
is faced with a directionality problem. The antiparallel nature of duplex DNA permits the …

The physical organization of DNA enzymes at a replication fork enables efficient copying of
two antiparallel DNA strands, yet dynamic protein interactions within the replication complex …

Cells and viruses possess several known 'restart'pathways to overcome lesions during DNA
replication. However, these 'bypass' pathways leave a gap in replicated DNA or require …