A Dosemeci, AJ Makusky… - Molecular & Cellular …, 2007 - ASBMB
Postsynaptic density protein 95 (PSD-95), a specialized scaffold protein with multiple protein interaction domains, forms the backbone of an extensive postsynaptic protein complex that …
JF Sturgill, P Steiner, BL Czervionke… - Journal of …, 2009 - Soc Neuroscience
The postsynaptic density (PSD) consists of a lattice-like array of interacting proteins that organizes and stabilizes receptors, ion channels, structural, and signaling proteins …
DJ Keith, A El-Husseini - Frontiers in molecular neuroscience, 2008 - frontiersin.org
Excitability of individual neurons dictates the overall excitation in specifi c brain circuits. This process is thought to be regulated by molecules that regulate synapse number, morphology …
Members of the postsynaptic density-95 (PSD95)/synapse-associated protein-90 (SAP90) family of scaffolding proteins contain a common set of modular protein interaction motifs …
MJ Kim, K Futai, J Jo, Y Hayashi, K Cho, M Sheng - Neuron, 2007 - cell.com
The scaffold protein PSD-95 promotes the maturation and strengthening of excitatory synapses, functions that require proper localization of PSD-95 in the postsynaptic density …
PSD-95, a synaptic scaffolding protein, plays important roles in the regulation of dendritic spine morphology and glutamate receptor signaling. We have recently shown that PSD-95 …
Most excitatory synapses terminate on dendritic spines. Spines vary in size, and their volumes are proportional to the area of the postsynaptic density (PSD) and synaptic …
SE Craven, DS Bredt - Journal of Biological Chemistry, 2000 - ASBMB
Synaptic function requires proper localization of proteins at synaptic sites. Targeting of the postsynaptic density protein 95 (PSD-95) relies on multiple signals within the protein …
AE El-Husseini, SE Craven, DM Chetkovich… - The Journal of cell …, 2000 - rupress.org
Postsynaptic density-95 (PSD-95/SAP-90) is a palmitoylated peripheral membrane protein that scaffolds ion channels at excitatory synapses. To elucidate mechanisms for postsynaptic …