Posttranslational modifications regulate the postsynaptic localization of PSD-95

D Vallejo, JF Codocedo, NC Inestrosa - Molecular neurobiology, 2017 - Springer
The postsynaptic density (PSD) consists of a lattice-like array of interacting proteins that
organizes and stabilizes synaptic receptors, ion channels, structural proteins, and signaling …

Composition of the synaptic PSD-95 complex

A Dosemeci, AJ Makusky… - Molecular & Cellular …, 2007 - ASBMB
Postsynaptic density protein 95 (PSD-95), a specialized scaffold protein with multiple protein
interaction domains, forms the backbone of an extensive postsynaptic protein complex that …

Distinct domains within PSD-95 mediate synaptic incorporation, stabilization, and activity-dependent trafficking

JF Sturgill, P Steiner, BL Czervionke… - Journal of …, 2009 - Soc Neuroscience
The postsynaptic density (PSD) consists of a lattice-like array of interacting proteins that
organizes and stabilizes receptors, ion channels, structural, and signaling proteins …

Excitation control: balancing PSD-95 function at the synapse

DJ Keith, A El-Husseini - Frontiers in molecular neuroscience, 2008 - frontiersin.org
Excitability of individual neurons dictates the overall excitation in specifi c brain circuits. This
process is thought to be regulated by molecules that regulate synapse number, morphology …

Postsynaptic targeting of alternative postsynaptic density-95 isoforms by distinct mechanisms

DM Chetkovich, RC Bunn, SH Kuo… - Journal of …, 2002 - Soc Neuroscience
Members of the postsynaptic density-95 (PSD95)/synapse-associated protein-90 (SAP90)
family of scaffolding proteins contain a common set of modular protein interaction motifs …

Synaptic accumulation of PSD-95 and synaptic function regulated by phosphorylation of serine-295 of PSD-95

MJ Kim, K Futai, J Jo, Y Hayashi, K Cho, M Sheng - Neuron, 2007 - cell.com
The scaffold protein PSD-95 promotes the maturation and strengthening of excitatory
synapses, functions that require proper localization of PSD-95 in the postsynaptic density …

To branch or not to branch: How PSD-95 regulates dendrites and spines

ES Sweet, CY Tseng, B Firestein - Bioarchitecture, 2011 - Taylor & Francis
PSD-95, a synaptic scaffolding protein, plays important roles in the regulation of dendritic
spine morphology and glutamate receptor signaling. We have recently shown that PSD-95 …

Rapid redistribution of synaptic PSD-95 in the neocortex in vivo

NW Gray, RM Weimer, I Bureau, K Svoboda - PLoS biology, 2006 - journals.plos.org
Most excitatory synapses terminate on dendritic spines. Spines vary in size, and their
volumes are proportional to the area of the postsynaptic density (PSD) and synaptic …

Synaptic targeting of the postsynaptic density protein PSD-95 mediated by a tyrosine-based trafficking signal

SE Craven, DS Bredt - Journal of Biological Chemistry, 2000 - ASBMB
Synaptic function requires proper localization of proteins at synaptic sites. Targeting of the
postsynaptic density protein 95 (PSD-95) relies on multiple signals within the protein …

Dual palmitoylation of PSD-95 mediates its vesiculotubular sorting, postsynaptic targeting, and ion channel clustering

AE El-Husseini, SE Craven, DM Chetkovich… - The Journal of cell …, 2000 - rupress.org
Postsynaptic density-95 (PSD-95/SAP-90) is a palmitoylated peripheral membrane protein
that scaffolds ion channels at excitatory synapses. To elucidate mechanisms for postsynaptic …