Elevated interstitial fluid pressure and solid stress within tumors contribute to poor
intratumoral distribution of nanomedicine. In this study, we hypothesized that the presence of …

Effective drug delivery to a tumor depends on favorable blood perfusion within the tumor. As
an important component of tumor extracellular matrix, fibrin is abundant near tumor vessels …

Recent advances in nanotechnology have offered new hope for cancer detection,
prevention, and treatment. While the enhanced permeability and retention effect has served …

Nanomedicines including liposomes, micelles, and nanoparticles based on the enhanced
permeability and retention (EPR) effect have become the mainstream for tumor treatment …

Preclinical research has demonstrated that nanoparticles and macromolecules can
accumulate in solid tumors due to the enhanced permeability and retention effect. However …

Enhancing the tumor-targeted delivery efficiency of nanoparticles is necessary for improving
their therapeutic efficacy, yet how to fulfill this, especially in a practical manner, remains a …

Effectiveness of nanomedicines in cancer therapy is limited in part by inadequate delivery
and transport in tumor interstitium. This article reviews the experimental approaches to …

A major challenge in the development of cancer nanomedicine is the inability for
nanomaterials to efficiently penetrate and deliver therapeutic agents into solid tumors …

The extraordinary growth and progression of tumor require enormous nutrient and energy.
Unregulated behaviors of cancer cell progressing and persistently change of tumor …

Nanocarrier-based cancer chemotherapeutics are thought to increase therapeutic efficiency
and reduce the side effects of associated chemotherapeutic agents by altering the agents' …