Mycobacterium tuberculosis has succeeded as a human pathogen for tens of thousands of
years thanks to its ability to resist and adapt to the adverse conditions it encounters upon …

The bacteriostatic and bactericidal effects and the transcriptional response of
Mycobacterium tuberculosis to representative oxidative and nitrosative stresses were …

The infectious life cycle of Mycobacterium tuberculosis (Mtb), as it relates to the disease
tuberculosis (TB) in humans, begins from release of the bacilli in fine aerosol particles when …

The establishment of Mycobacterium tuberculosis (Mtb) long-term infection in vivo depends
on several factors, one of which is the availability of key nutrients such as iron (Fe). The …

In high enough concentrations, such as produced by inducible nitric oxide synthase (iNOS),
reactive nitrogen species (RNS) can kill Mycobacterium tuberculosis (Mtb). Lesional …

Progression and outcome of tuberculosis is governed by extensive crosstalk between
pathogen and host. Analyses of global changes in gene expression during immune …

Defence against oxidative stress is crucial for Mycobacterium tuberculosis to survive and
replicate within macrophages. Mycobacteria have evolved multilayer antioxidant systems …

Regulating responses to stress is critical for all bacteria, whether they are environmental,
commensal, or pathogenic species. For pathogenic bacteria, successful colonization and …

Mycobacterium tuberculosis encounters a range of stimuli in the host. Understanding the
environmental cues that initiate the transcriptional response of M. tuberculosis, which enable …

Background As an intracellular human pathogen, Mycobacterium tuberculosis (Mtb) is facing
multiple stressful stimuli inside the macrophage and the granuloma. Understanding Mtb …