The efficacy of β-lactam antibiotics is threatened by the emergence and global spread of
metallo-β-lactamase (MBL) mediated resistance, specifically New Delhi metallo-β-lactamase …

The emergence and global spread of metallo-β-lactamase (MBL) mediated resistance to
almost all β-lactam antibacterials poses a serious threat to public health. Since no clinically …

Resistance to β-lactam antibiotics can be mediated by metallo-β-lactamase enzymes
(MBLs). An MBL inhibitor could restore the effectiveness of β-lactams. We report on the …

The inhibition of metallo-β-lactamases (MBL) can prevent the hydrolysis of β-lactam
antibiotics and hence is a promising strategy for the treatment of antibiotic resistant …

A SAR study on derivatives of 2-amino-1-benzyl-4, 5-diphenyl-1 H-pyrrole-3-carbonitrile 5a
revealed that the 3-carbonitrile group, vicinal 4, 5-diphenyl and N-benzyl side chains of the …

There are currently no clinically available inhibitors of metallo-β-lactamases (MBLs). These
enzymes confer resistance to bacteria against a broad range of commonly used β-lactam …

Bacterial resistance has become a worldwide concern after the emergence of metallo-β-
lactamases (MBLs). They represent one of the major mechanisms of bacterial resistance …

Abstract Metallo-β-lactamases (MBLs), such as New Delhi metallo-β-lactamase (NDM-1)
have spread world-wide and present a serious threat. Expression of MBLs confers …

The rise of antimicrobial resistance (AMR) worldwide and the increasing spread of multi-
drug-resistant organisms expressing metallo-β-lactamases (MBL) require the development …

There are currently no clinically useful inhibitors against metallo-β-lactamases (MBLs),
enzymes that confer resistance against a broad spectrum of commonly used antibiotics and …