Viral vector malaria vaccines induce high-level T cell and antibody responses in West African children and infants
Heterologous prime-boosting with viral vectors encoding the pre-erythrocytic antigen
thrombospondin-related adhesion protein fused to a multiple epitope string (ME-TRAP) …
thrombospondin-related adhesion protein fused to a multiple epitope string (ME-TRAP) …
Safety and immunogenicity of malaria vectored vaccines given with routine expanded program on immunization vaccines in Gambian infants and neonates: a …
Background Heterologous prime-boost vaccination with chimpanzee adenovirus 63
(ChAd63) and modified vaccinia virus Ankara (MVA) encoding multiple epitope string …
(ChAd63) and modified vaccinia virus Ankara (MVA) encoding multiple epitope string …
Safety and immunogenicity of ChAd63 and MVA ME-TRAP in West African children and infants
MO Afolabi, AB Tiono, UJ Adetifa, JB Yaro… - Molecular Therapy, 2016 - cell.com
Malaria remains a significant global health burden and a vaccine would make a substantial
contribution to malaria control. Chimpanzee Adenovirus 63 Modified Vaccinia Ankara …
contribution to malaria control. Chimpanzee Adenovirus 63 Modified Vaccinia Ankara …
Safety, Immunogenicity and Efficacy of Prime-Boost Vaccination with ChAd63 and MVA Encoding ME-TRAP against Plasmodium falciparum Infection in Adults in …
VA Mensah, A Gueye, M Ndiaye, NJ Edwards… - PLoS …, 2016 - journals.plos.org
Malaria transmission is in decline in some parts of Africa, partly due to the scaling up of
control measures. If the goal of elimination is to be achieved, additional control measures …
control measures. If the goal of elimination is to be achieved, additional control measures …
A randomised, double-blind, controlled vaccine efficacy trial of DNA/MVA ME-TRAP against malaria infection in Gambian adults
VS Moorthy, EB Imoukhuede, P Milligan… - PLoS …, 2004 - journals.plos.org
Background Many malaria vaccines are currently in development, although very few have
been evaluated for efficacy in the field. Plasmodium falciparum multiple epitope (ME) …
been evaluated for efficacy in the field. Plasmodium falciparum multiple epitope (ME) …
[HTML][HTML] Methods for determining vaccine efficacy and effectiveness and the main barriers to developing a fully deployable malaria vaccine
C Guinovart, PL Alonso - … and Defeating the Intolerable Burden of …, 2007 - ncbi.nlm.nih.gov
The past few years have witnessed the appearance of public-private partnerships and a
significant increase of resources devoted to the development of malaria vaccines. Lessons …
significant increase of resources devoted to the development of malaria vaccines. Lessons …
Translating the immunogenicity of prime-boost immunization with ChAd63 and MVA ME-TRAP from malaria naive to malaria-endemic populations
To induce a deployable level of efficacy, a successful malaria vaccine would likely benefit
from both potent cellular and humoral immunity. These requirements are met by a …
from both potent cellular and humoral immunity. These requirements are met by a …
Clinical development of malaria vaccines: should earlier trials be done in malaria endemic countries?
R Chilengi - Human Vaccines, 2009 - Taylor & Francis
Clinical development of malaria vaccines has had remarkable achievements in the past
decade, but an efficacious vaccine is yet to be licensed. There are many scientific and …
decade, but an efficacious vaccine is yet to be licensed. There are many scientific and …
T Cell Responses to the RTS,S/AS01E and RTS,S/AS02D Malaria Candidate Vaccines Administered According to Different Schedules to …
Background The Plasmodium falciparum pre-erythrocytic stage candidate vaccine RTS, S is
being developed for protection of young children against malaria in sub-Saharan Africa …
being developed for protection of young children against malaria in sub-Saharan Africa …
Safety and High Level Efficacy of the Combination Malaria Vaccine Regimen of RTS,S/AS01B With Chimpanzee Adenovirus 63 and Modified Vaccinia Ankara …
Background. The need for a highly efficacious vaccine against Plasmodium falciparum
remains pressing. In this controlled human malaria infection (CHMI) study, we assessed the …
remains pressing. In this controlled human malaria infection (CHMI) study, we assessed the …