Pathogens, expressing metallo-β-lactamases (MBLs), become resistant against most β-
lactam antibiotics. Besides the dragging search for new antibiotics, development of MBL …

The global overuse of antibiotics has led to the emergence of drug-resistant pathogenic
bacteria. Bacteria can combat β-lactams by expressing β-lactamases. Inhibitors of one class …

Metallo-β-lactamase (MBL) production in Gram-negative bacteria is an important contributor
to β-lactam antibiotic resistance. Combining β-lactams with β-lactamase inhibitors (BLIs) is a …

Resistance to β-lactam antibiotics is rapidly growing, substantially due to the spread of
serine-β-lactamases (SBLs) and metallo-β-lactamases (MBLs), which efficiently catalyse β …

Resistance to β‐lactam antibacterials is commonly associated with the production of the
serine β‐lactamases (SBLs) and/or metallo‐β‐lactamases (MBLs). Although clinically useful …

The prevalence of infections caused by metallo-β-lactamase (MBL) expressing Gram-
negative bacteria has grown at an alarming rate in recent years. Despite the fact that MBLs …

The worldwide proliferation of life-threatening metallo-β-lactamase (MBL)-producing Gram-
negative bacteria is a serious concern to public health. MBLs are compromising the …

Metallo-β-lactamases (MBLs) are zinc-dependent enzymes capable of hydrolyzing all
bicyclic β-lactam antibiotics, posing a great threat to public health. However, there are …

ABSTRACT Introduction Metallo-β-lactamases (MBLs) are enzymes produced by bacteria
that confer resistance to most β-lactam antibiotics, including carbapenems, which have the …

The β-lactam antibiotics are essential for the treatment of a wide range of human bacterial
diseases. However, a class of zinc-dependent hydrolases known as the metallo-β …