Transcriptional control requires epigenetic changes directed by mitochondrial tricarboxylic
acid (TCA) cycle metabolites. In the mouse embryo, global epigenetic changes occur during …

Nucleic acid and histone modifications critically depend on the tricarboxylic acid (TCA) cycle
for substrates and cofactors. Although a few TCA cycle enzymes have been reported in the …

Background Virtually all eukaryotic cells contain spatially distinct genomes, a single nuclear
genome that harbours the vast majority of genes and much smaller genomes found in …

The scope and variety of the metabolic intermediates from the mitochondrial tricarboxylic
acid (TCA) cycle that are engaged in epigenetic regulation of the chromatin function in the …

As a consequence of recent discoveries of intimate involvement of mitochondria with key
cellular processes, there has been a resurgence of interest in all aspects of mitochondrial …

Mitochondria are central hubs for cellular metabolism, coordinating a variety of metabolic
reactions crucial for human health. Mitochondria provide most of the cellular energy via their …

Mitochondria are specialized compartments that produce requisite ATP to fuel cellular
functions and serve as centers of metabolite processing, cellular signaling, and apoptosis …

The biogenesis and function of mitochondria rely upon the regulated expression of nuclear
genes. Recent evidence points to both transcriptional activators and coactivators as …

Epigenetic modifications influence gene expression programs ultimately dictating
physiological outcomes. In the past decades, an increasing body of work has demonstrated …

We are witnessing a period of renewed interest in the biology of the mitochondrion. The
mitochondrion serves a critical function in the maintenance of cellular energy stores …