Microglia emerge as central players in brain disease

MW Salter, B Stevens - Nature medicine, 2017 - nature.com
There has been an explosion of new findings recently giving us insights into the involvement
of microglia in central nervous system (CNS) disorders. A host of new molecular tools and …

[HTML][HTML] Microglia in health and disease: the strength to be diverse and reactive

O Uriarte Huarte, L Richart, M Mittelbronn… - Frontiers in Cellular …, 2021 - frontiersin.org
Microglia are the resident immune effector cells of the central nervous system (CNS) rapidly
reacting to any perturbation in order to maintain CNS homeostasis. Although their …

Microglia function in the central nervous system during health and neurodegeneration

M Colonna, O Butovsky - Annual review of immunology, 2017 - annualreviews.org
Microglia are resident cells of the brain that regulate brain development, maintenance of
neuronal networks, and injury repair. Microglia serve as brain macrophages but are distinct …

[HTML][HTML] Microglial contribution to the pathology of neurodevelopmental disorders in humans

R Matuleviciute, ET Akinluyi, TAO Muntslag… - Acta …, 2023 - Springer
Microglia are the brain's resident macrophages, which guide various developmental
processes crucial for brain maturation, activity, and plasticity. Microglial progenitors enter the …

[HTML][HTML] Microglia biology: one century of evolving concepts

M Prinz, S Jung, J Priller - Cell, 2019 - cell.com
Microglia were first recognized as a distinct cell population in the CNS one century ago. For
a long time, they were primarily considered to be phagocytes responsible for removing …

[HTML][HTML] Sublime microglia: expanding roles for the guardians of the CNS

MW Salter, S Beggs - Cell, 2014 - cell.com
Recent findings challenge the concept that microglia solely function in disease states in the
central nervous system (CNS). Rather than simply reacting to CNS injury, infection, or …

New insights into microglia–neuron interactions: a neuron's perspective

B Pósfai, C Cserép, B Orsolits, Á Dénes - Neuroscience, 2019 - Elsevier
Microglia are the primary immune cells of the central nervous system. However, recent data
indicate that microglia also contribute to diverse physiological and pathophysiological …

The identity and function of microglia in neurodegeneration

WM Song, M Colonna - Nature immunology, 2018 - nature.com
The predominant type of immune cell in the brain is the microglia, a type of tissue-resident
macrophage. In a variety of neurodegenerative settings, microglia alter their transcriptional …

The role of microglia in the healthy brain

MÈ Tremblay, B Stevens, A Sierra, H Wake… - Journal of …, 2011 - Soc Neuroscience
Microglia were recently shown to play unexpected roles in normal brain development and
adult physiology. This has begun to dramatically change our view of these resident …

Microglia: active sensor and versatile effector cells in the normal and pathologic brain

UK Hanisch, H Kettenmann - Nature neuroscience, 2007 - nature.com
Microglial cells constitute the resident macrophage population of the CNS. Recent in vivo
studies have shown that microglia carry out active tissue scanning, which challenges the …