abstract There is preclinical and clinical evidence that vagus nerve stimulation modulates
both pain and mood state. Mechanistic studies show brainstem circuitry involved in pain …

There is preclinical and clinical evidence that vagus nerve stimulation modulates both pain
and mood state. Mechanistic studies show brainstem circuitry involved in pain modulation by …

Objectives: Pain is a complex common health problem, with important implications for quality
of life and with huge economic consequences. Pain can be elicited due to tissue damage, as …

Objective: To test whether electric stimulation of the vagus nerve has an antinociceptive
effect in humans. Background: In a variety of animal studies, vagus nerve stimulation was …

Left vagus nerve stimulation reduces pain perception in humans. In animal studies it has
been shown that beyond the inhibitory effect, which the vagus nerve exerts via its …

BACKGROUND: Previous research suggests that vagus nerve stimulation (VNS) affects pain
perception in epilepsy patients, with acute VNS decreasing pain thresholds and chronic …

The vagus nerve is the largest cranial nerve of the human body. It provides an extensive
network of afferent and efferent pathways that interface between the higher central nervous …

Vagus nerve stimulation (VNS), already used as a treatment for refractory epilepsy, has also
been assessed for its analgesic effect. Numerous studies report that electrical stimulation of …

Vagus nerve stimulation (VNS) can modulate vagal activity and neuro-immune
communication. Human and animal studies have provided growing evidence that VNS can …

BACKGROUND: Recent preclinical work strongly suggests that vagus nerve stimulation
efficiently modulates nociception and pain processing in humans. Most recently, a medical …