Hexokinases II (HK2) is a hub in the regulation of cancer cell glycolysis. Here we reported
deguelin, a natural compound which has been studied in various tumor types, has a …

Deregulation of glycolysis is a common phenomenon in human non-small cell lung cancer
(NSCLC). In the present study, we reported the natural compound, piperlongumine, has a …

Deguelin, the main components from Mundulea sericea, was reported to suppress the
growth of various cancer cells. However, the effect of Deguelin on tumor cell invasion and …

Deguelin, a naturally occurring rotenoid of the flavonoid family, is known to be an Akt
inhibitor, to have chemopreventive activities and anti‐tumor effect on several cancers. In this …

Lung cancer is the leading cause of cancer mortality around the world. Despite advances in
the targeted therapy, patients with lung squamous cell carcinoma (SCC) still benefit few from …

Cancer is an anomalous growth and differentiation of cells known to be governed by
oncogenic factors. Plant-based natural metabolites have been well recognized to possess …

Deguelin has shown promising chemopreventive and therapeutic activities in diverse types
of cancers. However, the potential side effect of deguelin over a certain dose could be the …

Head and neck squamous cell carcinoma (HNSCC) represents more than 5% of all cancers
diagnosed annually in United States and around the world. Despite advances in the …

Deguelin is a rotenoid compound that exists in abundant quantities in the bark, roots, and
leaves of the Leguminosae family of plants. An analysis of evidence from both in vitro and in …

Background Treatment of breast cancer patients with antiestrogens and aromatase inhibitor
(s) or Herceptin have shown significant success in steroid receptor positive or Her-2+ breast …