To date, gene expression has been characterized in over one thousand species across
more than a million experimental conditions. With this wealth of data, it is possible to …

Biological systems are perhaps the ultimate complex systems, uniquely capable of
processing and communicating information, reproducing in their lifetimes, and adapting in …

Gene regulation in humans and other mammalian organisms is complex with many different
layers. Despite huge advances in biomedical research, our ability to build a comprehensive …

Cellular transcriptional programs driven by genetic and epigenetic mechanisms could be
better understood by integrating “omics” data and subsequently modeling the gene …

It has become increasingly evident that the use of large-scale experimental data and the
application of principles from systems biology are gaining widespread acceptance in …

In recent years, a number of technical and experimental advances have allowed us to obtain
an unprecedented amount of information about living systems on a genomic scale. Although …

Systems biology requires development of computational tools and capabilities which enable
us to understand complex biological systems. Advances in measurement technology have …

It is estimated that at least 10-20% of the mammalian genome is dedicated towards
regulating the 1-2% of the genome that codes for proteins. This non-coding, regulatory layer …

The coordinated and dynamic modulation or interaction of genes or proteins acts as an
important mechanism used by a cell in functional regulation. Recent studies have shown …

Over the last decades, genomic data has become significantly cheaper to produce and more
ubiquitous. The analysis of such data can shed light on the functioning of organisms and …