Aldosterone and cortisol, the main mineralocorticoid and glucocorticoid hormones in
humans, are produced in the adrenal cortex, which is composed of three concentric zones …

Abstract Context: Adrenocortical adenomas (ACAs) are among the most frequent human
neoplasias. Genetic alterations affecting the cAMP/protein kinase A signaling pathway are …

The genetic alterations that cause the development of glucocorticoid and/or
mineralocorticoid producing benign adrenocortical tumors and hyperplasias have largely …

Benign adrenal tumors cover a spectrum of lesions with distinct morphology and steroid
secretion. Current classification is empirical. Beyond a few driver mutations …

Objective Co-secretion of cortisol and aldosterone can be observed in adrenal adenomas.
The aim of this study was to investigate the molecular characteristics of a co-existing …

Primary aldosteronism (PA) is a common cause of secondary hypertension. Recent
technological advances in genetic analysis have provided a better understanding of the …

Aldosterone-producing adenoma (APA) cause primary aldosteronism—the most frequent
form of secondary hypertension. Somatic mutations in genes coding for ion channels and …

Objective Cortisol excess due to adrenal adenomas or hyperplasia causes Cushing's
syndrome. Recent genetic studies have identified a somatic PRKACA L206R mutation as a …

Adrenocortical causes of Cushing's syndrome include the following: common cortisol-
producing adenomas, which are usually isolated (without associated tumors) and sporadic …

The genetic basis of most types of adrenal adenomas has been elucidated over the past
decade, leading to the association of adrenal gland pathologies with specific molecular …