The establishment and maintenance of chromatin states involves multiscale dynamic
processes integrating transcription factor and multiprotein effector dynamics, cycles of …

Connecting the molecular structure and function of chromatin across length and timescales
remains a grand challenge to understanding and engineering cellular behaviors. Across five …

Genetic and genomic techniques have proven incredibly powerful for identifying and
studying molecular players implicated in the epigenetic regulation of DNA-templated …

Chromatin is extensively chemically modified and thereby acts as a dynamic signaling
platform controlling gene function. Chromatin regulation is integral to cell differentiation …

Cells of a multicellular organism, all containing nearly identical genetic information, respond
to differentiation cues in variable ways. In addition, cells are plastic, able to execute their …

During development and differentiation, early inductive processes that influence cell fate at a
later stage leave marks at distinct gene loci that are maintained through several rounds of …

Differences in chromatin organization are key to the multiplicity of cell states that arise from a
single genetic background, yet the landscapes of in vivo tissues remain largely uncharted …

Chromatin, the template for epigenetic regulation, is a highly dynamic entity that is constantly
reshaped during early development and differentiation. Epigenetic modification of chromatin …

Understanding chromatin regulation holds enormous promise for controlling gene
regulation, predicting cellular identity, and developing diagnostics and cellular therapies …

During development and throughout life, a variety of specialized cells must be generated to
ensure the proper function of each tissue and organ. Chromatin plays a key role in …