An intra-amygdala circuit specifically regulates social fear learning

RC Twining, JE Vantrease, S Love, M Padival… - Nature …, 2017 - nature.com
Adaptive social behavior requires transmission and reception of salient social information.
Impairment of this reciprocity is a cardinal symptom of autism. The amygdala is a critical …

[HTML][HTML] Social circuits and their dysfunction in autism spectrum disorder

M Sato, N Nakai, S Fujima, KY Choe, T Takumi - Molecular Psychiatry, 2023 - nature.com
Social behaviors, how individuals act cooperatively and competitively with conspecifics, are
widely seen across species. Rodents display various social behaviors, and many different …

Prefrontal circuits guiding social preference: Implications in autism spectrum disorder

AV Fortier, OC Meisner, AR Nair… - … & Biobehavioral Reviews, 2022 - Elsevier
Abstract Although Autism Spectrum Disorder (ASD) is increasing in diagnostic prevalence,
treatment options are inadequate largely due to limited understanding of ASD's underlying …

Dynamics of social representation in the mouse prefrontal cortex

DR Levy, T Tamir, M Kaufman, A Parabucki… - Nature …, 2019 - nature.com
The prefrontal cortex (PFC) plays an important role in regulating social functions in
mammals, and its dysfunction has been linked to social deficits in neurodevelopmental …

Ucn3 and CRF-R2 in the medial amygdala regulate complex social dynamics

Y Shemesh, O Forkosh, M Mahn, S Anpilov… - Nature …, 2016 - nature.com
Social encounters are associated with varying degrees of emotional arousal and stress. The
mechanisms underlying adequate socioemotional balance are unknown. The medial …

Neural circuits for social cognition: implications for autism

M Fernández, I Mollinedo-Gajate, O Peñagarikano - Neuroscience, 2018 - Elsevier
Social neuroscience, the study of the neurobiological basis of social behavior, has become
a major area of current research in behavioral neuroscience and psychiatry, since many …

[HTML][HTML] A comprehensive assay of social motivation reveals sex-specific roles of autism-associated genes and oxytocin

SE Maloney, S Sarafinovska, C Weichselbaum… - Cell reports …, 2023 - cell.com
Social motivation is critical to the development of typical social functioning. Social
motivation, specifically one or more of its components (eg, social reward seeking or social …

[HTML][HTML] Reward learning improves social signal processing in autism model mice

J Kim, MW Jung, D Lee - Cell Reports, 2023 - cell.com
Social and reward signal processing and their association are critical elements of social
motivation. Despite the use of reward learning to improve the social interactions of patients …

Insular cortex projections to nucleus accumbens core mediate social approach to stressed juvenile rats

MM Rogers-Carter, A Djerdjaj, KB Gribbons… - Journal of …, 2019 - Soc Neuroscience
Social interactions are shaped by features of the interactants, including age, emotion, sex,
and familiarity. Age-specific responses to social affect are evident when an adult male rat is …

Role of BDNF in the development of an OFC-amygdala circuit regulating sociability in mouse and human

A Li, D Jing, DV Dellarco, BS Hall, R Yang… - Molecular …, 2021 - nature.com
Social deficits are common in many psychiatric disorders. However, due to inadequate tools
for manipulating circuit activity in humans and unspecific paradigms for modeling social …