Liposomes containing monophosphoryl lipid A and QS-21 serve as an effective adjuvant for soluble circumsporozoite protein malaria vaccine FMP013
Malaria caused by Plasmodium falciparum continues to threaten millions of people living in
the tropical parts of the world. A vaccine that confers sterile and life-long protection remains …
the tropical parts of the world. A vaccine that confers sterile and life-long protection remains …
Safety, toxicity and immunogenicity of a malaria vaccine based on the circumsporozoite protein (FMP013) with the adjuvant army liposome formulation containing …
Antibodies to Circumsporozoite protein (CSP) confer protection against controlled human
malaria infection (CHMI) caused by the parasite Plasmodium falciparum. Although CSP is …
malaria infection (CHMI) caused by the parasite Plasmodium falciparum. Although CSP is …
Safety, Immunogenicity, and Efficacy of Plasmodium falciparum Repeatless Circumsporozoite Protein Vaccine Encapsulated in Liposomes
DG Heppner, DM Gordon, M Gross… - Journal of Infectious …, 1996 - academic.oup.com
Seventeen malaria-naive volunteers received a recombinant Plasmodium falciparum
vaccine (RLF) containing the carboxy-and the amino-terminal of the circumsporozoite …
vaccine (RLF) containing the carboxy-and the amino-terminal of the circumsporozoite …
First-in-human assessment of safety and immunogenicity of low and high doses of Plasmodium falciparum malaria protein 013 (FMP013) administered intramuscularly …
JN Hutter, PM Robben, C Lee, M Hamer, JE Moon… - Vaccine, 2022 - Elsevier
The global burden of malaria remains substantial. Circumsporozoite protein (CSP) has been
demonstrated to be an effective target antigen, however, improvements that offer more …
demonstrated to be an effective target antigen, however, improvements that offer more …
Low dose recombinant full-length circumsporozoite protein-based Plasmodium falciparum vaccine is well-tolerated and highly immunogenic in phase 1 first-in-human …
DAJ Friedman-Klabanoff, AA Berry, MA Travassos… - Vaccine, 2021 - Elsevier
Plasmodium falciparum circumsporozoite protein (CSP) is a major sporozoite surface
protein and a key target of pre-erythrocytic malaria subunit vaccines. A full-length …
protein and a key target of pre-erythrocytic malaria subunit vaccines. A full-length …
Vaccine co-display of CSP and Pfs230 on liposomes targeting two Plasmodium falciparum differentiation stages
WC Huang, MT Mabrouk, L Zhou, M Baba… - Communications …, 2022 - nature.com
A vaccine targeting multiple stages of the Plasmodium falciparum parasite life cycle is
desirable. The sporozoite surface Circumsporozoite Protein (CSP) is the target of leading …
desirable. The sporozoite surface Circumsporozoite Protein (CSP) is the target of leading …
An epitope-based malaria vaccine targeting the junctional region of circumsporozoite protein
L Jelínková, H Jhun, A Eaton, N Petrovsky, F Zavala… - npj Vaccines, 2021 - nature.com
A malaria vaccine that elicits long-lasting protection and is suitable for use in endemic areas
remains urgently needed. Here, we assessed the immunogenicity and prophylactic efficacy …
remains urgently needed. Here, we assessed the immunogenicity and prophylactic efficacy …
Robust antibody and CD8+ T-cell responses induced by P. falciparum CSP adsorbed to cationic liposomal adjuvant CAF09 confer sterilizing immunity against …
Despite several decades of extensive research, the development of a highly efficacious
malaria vaccine has yet to be accomplished. While the RTS, S malaria vaccine candidate …
malaria vaccine has yet to be accomplished. While the RTS, S malaria vaccine candidate …
Immunogenicity of Plasmodium falciparum circumsporozoite protein multiple antigen peptide vaccine formulated with different adjuvants
TP Le, LWP Church, G Corradin, RL Hunter… - Vaccine, 1998 - Elsevier
Only low antibody levels were obtained from vaccinating human volunteers with singlechain
peptide from the Plasmodium falciparum circumsporozoite protein (PfCSP). This resulted in …
peptide from the Plasmodium falciparum circumsporozoite protein (PfCSP). This resulted in …
Rhesus macaque and mouse models for down-selecting circumsporozoite protein based malaria vaccines differ significantly in immunogenicity and functional …
Background Non-human primates, such as the rhesus macaques, are the preferred model
for down-selecting human malaria vaccine formulations, but the rhesus model is expensive …
for down-selecting human malaria vaccine formulations, but the rhesus model is expensive …