Adipocytes are the most abundant stromal partners in breast tissue. However, the crosstalk
between breast cancer cells and adipocytes has been given less attention compared to …

Background Obesity is associated with increased recurrence and reduced survival of breast
cancer. Adipocytes constitute a significant component of breast tissue, yet their role in …

Monocarboxylate transporters (MCTs) are transmembrane proteins that control the lactate
metabolism and associated with poor prognosis in solid tumours including breast cancer …

Mammary adipose tissue (AT) is necessary for breast epithelium. However, in breast cancer
(BC), cell-cell interactions are deregulated as the tumor chronically modifies AT …

Growing evidence indicates that adiposity is associated with raised cancer incidence,
morbidity and mortality. In a subset of tumors, cancer cell growth and/or metastasis …

The cellular components of microenvironment are partners of cancer cells, sharing soluble
factors and organic molecules to accomplish tumor energy and biomass demands. We …

The tumor stroma is a heterogeneous ecosystem comprising matrix, fibroblasts, and immune
cells and has an important role in cancer progression. Adipocytes constitute a major …

Understanding the mechanisms that enable cancer cells to metastasize is essential in
preventing cancer progression. Here we examine the metabolic adaptations of metastasis …

Background To determine whether adipocyte-derived lipids could be transferred into breast
cancer cells and investigate the underlying mechanisms of subsequent lipolysis and fatty …

In breast cancer, a key feature of peritumoral adipocytes is their loss of lipid content
observed both in vitro and in human tumors. The free fatty acids (FFAs), released by …