Background The isocitrate dehydrogenase (IDH) gene family expresses key functional
metabolic enzymes in the Krebs cycle and mediates the epigenetic reprogramming, which …

The mitochondrion is an important organelle and provides energy for a plethora of
intracellular reactions. Metabolic dysregulation has dire consequences for the cell, and …

ABSTRACT Introduction: In August 2017, the United States Federal Drug Administration
(FDA) approved enasidenib (Idhifa, Celgene/Agios) for adults with relapsed and refractory …

Hotspot mutations in the isocitrate dehydrogenase 1 (IDH1) gene occur in a number of
human cancers and confer a neomorphic enzyme activity that catalyzes the conversion of α …

Uncertainty about controls on long-term carbon (C) and nitrogen (N) balance, turnover, and
isotopic composition currently limits our ability to predict ecosystem response to disturbance …

Cancer cells reprogram cellular metabolism to support the malignant features of tumors,
such as rapid growth and proliferation. The cancer promoting effects of metabolic …

Cellular plasticity, or the ability of a cancer cell to adapt to changes in the microenvironment,
is a major determinant of cell survival and functionality that require the coordination of …

Hypoxia-inducible transcription factors (HIFs) facilitate cellular adaptations to low-oxygen
environments. However, it is increasingly recognised that HIFs may be activated in response …

Cellular quiescence is a reversible, non-cycling state controlled by epigenetic,
transcriptional and niche-associated molecular factors. Quiescence is a condition where …

Acute myeloid leukemia (AML) is a debilitating and life-threatening condition, especially for
elderly patients who account for over 50% of diagnoses. For over four decades, standard …