miR-22/KAT6B axis is a chemotherapeutic determiner via regulation of PI3k-Akt-NF-kB pathway in tongue squamous cell carcinoma

Y Gu, H Liu, F Kong, J Ye, X Jia, Z Zhang, N Li… - Journal of Experimental …, 2018 - Springer
Background Tongue squamous cell carcinoma (TSCC) is the most common oral cancer.
Neoadjuvant systemic treatment before or after surgery for advanced TSCC is considered …

Recent development of genetic code expansion for posttranslational modification studies

H Chen, S Venkat, P McGuire, Q Gan, C Fan - Molecules, 2018 - mdpi.com
Nowadays advanced mass spectrometry techniques make the identification of protein
posttranslational modifications (PTMs) much easier than ever before. A series of proteomic …

Engineered nucleic acids and methods of use thereof

S Bancel, JP Schrum, A Aristarkhov - US Patent 10,022,425, 2018 - Google Patents
DRTQHJPVMGBUCF-XVFCMESISA-N Uridine Chemical class O [C@@ H] 1 [C@
H](O)[C@@ H](CO) O [C@ H] 1N1C (= O) NC (= O) C= C1 DRTQHJPVMGBUCF …

Epigenetic regulation of neuroblastoma development

K Durinck, F Speleman - Cell and Tissue Research, 2018 - Springer
In recent years, technological advances have enabled a detailed landscaping of the
epigenome and the mechanisms of epigenetic regulation that drive normal cell function …

Influenza A virus nucleoprotein is acetylated by histone acetyltransferases PCAF and GCN5

D Hatakeyama, M Shoji, S Yamayoshi, R Yoh… - Journal of Biological …, 2018 - ASBMB
Histone acetylation plays crucial roles in transcriptional regulation and chromatin
organization. Viral RNA of the influenza virus interacts with its nucleoprotein (NP), whose …

SUV39H2 promotes colorectal cancer proliferation and metastasis via tri-methylation of the SLIT1 promoter

W Shuai, J Wu, S Chen, R Liu, Z Ye, C Kuang, X Fu… - Cancer Letters, 2018 - Elsevier
Abstract Suppressor of variegation 3–9 homolog 2 (SUV39H2) is a member of the SUV39H
subfamily of lysine methyltransferases. Its role in colorectal cancer (CRC) proliferation and …

Repression of human and mouse brain inflammaging transcriptome by broad gene-body histone hyperacetylation

H Cheng, H Xuan, CD Green, Y Han… - Proceedings of the …, 2018 - National Acad Sciences
Brain “inflammaging,” a low-grade and chronic inflammation, is a major hallmark for aging-
related neurodegenerative diseases. Here, by profiling H3K27ac and gene expression …

Novel role of forkhead box O 4 transcription factor in cancer: bringing out the good or the bad

S Jiang, Z Yang, S Di, W Hu, Z Ma, F Chen… - Seminars in Cancer …, 2018 - Elsevier
Forkhead box O (FOXO) family has recently been highlighted as important transcriptional
regulators associated with many diverse carcinomas. Although redundant functionality …

Chemical biology approaches for investigating the functions of lysine acetyltransferases

M He, Z Han, L Liu, YG Zheng - … Chemie International Edition, 2018 - Wiley Online Library
The side‐chain acetylation of lysine residues in histones and non‐histone proteins
catalyzed by lysine acetyltransferases (KATs) represents a widespread posttranslational …

Establishment of dimethyl labeling-based quantitative acetylproteomics in Arabidopsis

S Liu, F Yu, Z Yang, T Wang, H Xiong, C Chang… - Molecular & Cellular …, 2018 - ASBMB
Protein acetylation, one of many types of post-translational modifications (PTMs), is involved
in a variety of biological and cellular processes. In the present study, we applied both CsCl …