Candida albicans is a major pathogenic fungus in humans, and meets at first the innate
immune cells, such as macrophages, in its host. One important strategy of the host cell to kill …

Background Maternal diabetes related neural tube defects (NTDs) are a result of oxidative
stress and apoptosis. However, the molecular mechanism behind the pathogenesis is not …

A large volume of research now provides evidence correlating aberrant histone deacetylase
(HDAC) activities and hypoacetylation of histones to disruptions in synaptic plasticity …

Liver organogenesis requires complex cell-cell interactions between hepatic endoderm cells
and adjacent cell niches. Endothelial cells are key players for endoderm hepatic fate …

Background Histone modifications are critical in regulating neuronal processes. However,
the impacts of individual histone modifications on learning and memory are elusive. Here …

Histone modifications provide an important layer of regulation for chromatin functions and
are critical for processes ranging from DNA replication to transcription, from cell-cycle …

The nucleosomal organization of chromatin using histone proteins is a fundamental and
ubiquitous feature of eukaryotic nuclei, with the major exception of dinoflagellates. Although …

Abstract p300/CBP Associated Factor (PCAF), a GNAT family member protein, represent a
valid target for therapeutic interventions since its dysfunction has implicated in variety of …

Reverse genetics is a promising strategy for elucidating the regulatory mechanisms involved
in secondary metabolism and development in fungi. Previous studies have demonstrated …

Epigenetic modifications are the heritable changes in gene expression patterns that are
independent of primary DNA sequence changes and affect the outcome of a locus or …