Mental disorders account for around one-third of disability worldwide and cause enormous
personal and societal burden. Current pharmacotherapies and nonpharmacotherapies do …

We present the largest exome sequencing study to date focused on rare variation in autism
spectrum disorder (ASD)(n= 35,584). Integrating de novo and case-control variation with an …

Matt was in many ways the stereotypical “all-American” teenager: a multisport athlete, class
president, and valedictorian of his high school. It seemed preordained that he would attend …

Postmortem studies in patients with schizophrenia (SCZ) have revealed deficits in
myelination, abnormalities in myelin gene expression and altered numbers of …

Recent large-scale genetic approaches, such as genome-wide association studies, have
identified multiple genetic variations that contribute to the risk of mental illnesses, among …

Abstract Glypican 4 (Gpc4) is a heparan sulfate proteoglycan that regulates glutamatergic
synapse formation and function in the developing brain. Gpc4 KO mice have been shown to …

Post-traumatic stress disorder (PTSD) is a common and debilitating disorder. The risk of
PTSD following trauma is heritable, but robust common variants have yet to be identified by …

Synapse formation is mediated by a surprisingly large number and wide variety of genes
encoding many different protein classes. One of the families increasingly implicated in …

The requirement of innovative big data analytics has become a critical success factor for
research in biological psychiatry. Integrative analyses across distributed data resources are …

Genetic variants associated with autism spectrum disorders (ASDs) are enriched in genes
encoding synaptic proteins and chromatin regulators. Although the role of synaptic proteins …