Affective disorders such as major depression and bipolar disorder are among the most
prevalent forms of mental illness and their etiologies involve complex interactions between …

There is empirical support for an association between childhood adverse life events and
psychopathology in adult offenders. This systematic review aims to summarise the literature …

Background Antidepressant treatment is associated with a high rate of poor response, and
thus, biomarker development is warranted. Methods We aimed to synthesize studies …

Childhood emotional abuse impairs emotion regulation and increases risk for major
depressive disorder in adulthood. Mounting evidence suggests that decreased resting-state …

Early life trauma (ELT) may increase the risk towards bipolar disorder (BD) and major
depression (MDD), disorders associated with activated neuro-oxidative and neuro …

Although the field of psychiatry has witnessed the proliferation of studies on Gene×
Environment (G× E) interactions, still limited is the knowledge we possess of G× E …

BackgroundThe medical burden in mood disorders is high; various factors are thought to
drive this pattern. Little research has examined the role of childhood maltreatment and its …

Background: Women with depression and childhood sexual abuse histories constitute more
than 20% of the female patient population in publicly funded community mental health …

In the treatment of major depression, childhood maltreatment (CM) has been associated with
an unfavorable outcome [1]. One possible exception might be psychotherapy with the …

Background Chronic depression (CD) is strongly associated with childhood maltreatment,
which has been proposed to lead to inefficient coping styles that are characterized by …