Background To date, the rapid clearance from ocular surface has been a huge obstacle for
using eye drops to treat glaucoma, since it has led to the short preocular residence time and …

Purpose:: We prepared and characterized topical ophthalmic formulations containing
brimonidine-loaded bioadhesive cationic chitosan or anionic alginate nanoparticles (NPs) …

This study was conducted to develop timolol maleate (TM)-loaded galactosylated chitosan
(GC) nanoparticles (NPs)(TM-GC-NPs) followed by optimization via a four-level and three …

The objective of the study was to investigate the potential of montmorillonite as a sustained
carrier in the preparation of drug-loaded nanoparticles for prolonged ocular application …

Despite frequent scientific efforts, efficient ocular drug delivery is a major challenge for
pharmaceutical scientists. Poor bioavailability of ophthalmic solutions can be overcome by …

Timolol Maleate is an aqueous soluble β-blocker antiglaucoma drug used to suppress
intraocular pressure. Several commercially available ocular formulations are not effective in …

Background To enhance ocular bioavailability, the traditional strategies have focused on
prolonging precorneal retention and improving corneal permeability by nano-carriers with …

Many effective anti-glaucoma drugs available for the treatment of ocular hypertension and
open angle glaucoma are associated with rapid and extensive precorneal loss caused by …

The aims of this study were to design and characterize methazolamide (MTZ)-loaded solid
lipid nanoparticles (SLN) with and without modification of low molecular weight chitosan …

Purpose To assess the potential of chitosan (CS) nanoparticles for ocular drug delivery by
investigating their intraocular retention by γ-scintigraphy and intraocular pressure reduction …